CAS 143827-20-7

creatinine-methyl-D3

Description:

Creatinine-methyl-D3, with the CAS number 143827-20-7, is a stable isotopic form of creatinine, which is a breakdown product of creatine phosphate in muscle and is typically excreted in urine. This compound is labeled with deuterium (D3), which is a heavier isotope of hydrogen, allowing for its use in various analytical techniques, particularly in metabolic studies and tracer experiments. The incorporation of deuterium enhances the sensitivity and specificity of mass spectrometry analyses, making it valuable in pharmacokinetic studies and biomarker research. Creatinine itself is a non-protein nitrogenous compound, and its levels in blood and urine are commonly used to assess kidney function. The methylation aspect refers to the addition of a methyl group, which can influence the compound's solubility and reactivity. Overall, creatinine-methyl-D3 serves as a useful tool in biochemical research, particularly in understanding metabolic pathways and the dynamics of creatinine in biological systems.

Formula: C₄H₄D₃N₃O

InChI: InChI=1/C4H7N3O/c1-7-2-3(8)6-4(7)5/h2H2,1H3,(H2,5,6,8)/i1D3

SMILES: C(N1CC(=NC1=N)O)([2H])([2H])[2H]

Synonyms:

• 2-Imino-1-(Trideuteriomethyl)Imidazolidin-4-One

Creatinine-d3

CAS: 143827-20-7

Formula: C₄H₄D₃N₃O

Color and Shape: White To Off-White Solid

Molecular weight: 116.14

Ref: 4Z-C-291

Creatinine-d3 (methyl-d3)

CAS: 143827-20-7

Purity: 99 atom % D

Color and Shape: White Solid

Molecular weight: 116.14

Ref: 3U-D3689

Creatinine-d3

Controlled Product

CAS: 143827-20-7

Applications Labelled Creatinine. The end product of creatine catabolism. Normal constituent of urine. Also found together with creatine in muscle tissues and blood. Occurs in all soils and in grain seeds and other vegetable matter. Has been found in certain fish and in crab meat extract.
References Folin, et al.: J. Biol. Chem., 17, 463 (1914),

Formula: C₄₂H₃H₄N₃O

Color and Shape: Off-White

Molecular weight: 116.14

Ref: TR-C781502

Creatinine-d3

Controlled Product

CAS: 143827-20-7

Creatinine-d3 is a radioactive form of creatinine that can be used to measure the degree of renal function in humans. Creatinine-d3 is a metabolite of creatine, which is synthesized primarily in muscle tissue and excreted by the kidney. Creatinine-d3 uptake reflects the glomerular filtration rate (GFR) and can be used as an indicator of renal disease. The metabolism of creatinine-d3 can be monitored using chromatographic methods, such as HPLC, or mass spectrometry. Due to its low detection limit, creatinine-d3 has been used for validation studies in humans and other mammals. It has also been used for the analysis of urine samples from healthy volunteers and patients with chronic kidney disease. Creatinine-d3 is often normalized to creatinine concentration in human urine samples because it does not react with other metabolites found in urine samples. This allows for accurate measurements

Formula: C₄H₄D₃N₃O

Purity: Min. 95%

Molecular weight: 116.13 g/mol

Ref: 3D-FC159510

4H-Imidazol-4-one, 2-amino-1,5-dihydro-1-(methyl-d3)-

CAS: 143827-20-7

Formula: C₄H₄D₃N₃O

Purity: 98%

Color and Shape: Solid

Molecular weight: 116.1364

Ref: IN-DA001IFF

Creatinine-D3

CAS: 143827-20-7

Creatinine-D3 is a deuterium-labeled Creatinine which is a break-down product of creatine phosphate in muscle.

Formula: C₄H₇N₃O

Purity: 98%

Color and Shape: Solid

Molecular weight: 116.14

Ref: TM-T19249