CAS 143899-90-5

Morphinan-3-amine,17-methyl-, (9a,13a,14a)- (9CI)

Description:

Morphinan-3-amine, 17-methyl-, (9a,13a,14a)-, also known by its CAS number 143899-90-5, is a chemical compound that belongs to the morphinan class of alkaloids. This substance is characterized by its complex bicyclic structure, which includes a phenanthrene core fused with a piperidine ring. Morphinan derivatives are often associated with various pharmacological activities, including analgesic and antitussive effects, due to their interaction with opioid receptors in the central nervous system. The specific configuration of this compound, indicated by the stereochemical descriptors (9a,13a,14a), suggests a particular three-dimensional arrangement that can influence its biological activity and potency. Morphinan-3-amine derivatives may also exhibit varying degrees of solubility in organic solvents and water, depending on their functional groups. As with many morphinan compounds, safety and regulatory considerations are important, particularly in the context of potential therapeutic applications or misuse. Further research is often necessary to fully understand the pharmacodynamics and toxicology associated with this compound.

Formula: C₁₇H₂₄N₂

Synonyms:

• AHN649
• Morphinan-3-amine, 17-methyl-, (9α,13α,14α)- (9CI)

Antidepressant agent 9

CAS: 143899-90-5

Antidepressant agent 9 (Compound 24) is an orally active inhibitor of NMDAR and SERT, with IC50 values of 3.50 μM and 1044 nM, respectively. It exhibits good metabolic stability and plasma exposure, and demonstrates antidepressant-like effects in the forced swim test in mice.

Formula: C₁₇H₂₄N₂

Color and Shape: Solid

Molecular weight: 256.386

Ref: TM-T205640