CAS 143900-44-1

(S)-1-Boc-3-hydroxypiperidine

Description:

(S)-1-Boc-3-hydroxypiperidine, with the CAS number 143900-44-1, is a chiral compound that belongs to the class of piperidine derivatives. It features a piperidine ring, which is a six-membered saturated nitrogen-containing heterocycle, and is characterized by the presence of a tert-butyloxycarbonyl (Boc) protecting group at the nitrogen atom and a hydroxyl group at the 3-position of the piperidine ring. This compound is typically used in organic synthesis, particularly in the preparation of pharmaceuticals and biologically active molecules, due to its ability to serve as a building block or intermediate. The Boc group is commonly employed to protect amines during chemical reactions, allowing for selective functionalization of other reactive sites. The stereochemistry indicated by the (S) designation suggests that the compound has a specific three-dimensional arrangement, which can influence its reactivity and interaction with biological targets. Overall, (S)-1-Boc-3-hydroxypiperidine is valued for its utility in synthetic chemistry and its potential applications in medicinal chemistry.

Formula: C₁₀H₁₉NO₃

InChI: InChI=1/C10H19NO3/c1-10(2,3)14-9(13)11-6-4-5-8(12)7-11/h8,12H,4-7H2,1-3H3/t8-/m0/s1

SMILES: CC(C)(C)OC(=O)N1CCC[C@@H](C1)O

Synonyms:

• (S)-1-N-Boc-3-Hydroxy-Piperidine
• (S)-3-Hydroxy-Piperidine-1-Carboxylic Acid Tert-Butyl Ester
• (S)-3-Hydroxy-1-(Tert-Butoxycarbonyl)Piperidine
• (S)-1-Boc-3-Piperidinol
• (S)-N-(Tert-Butoxycarbonyl)-3-Hydroxypiperidine Hydrochloride
• (S)-N-Boc-3-Hydroxy Piperidine
• (S)-Tert Butyl-3-Hydroxypiperidine-1-Carboxylate
• tert-butyl (3S)-3-hydroxypiperidine-1-carboxylate
• (S)-N-BOC-3-piperidinol
• (S)-N-Boc-3-piperidine

(S)-1-(tert-Butoxycarbonyl)-3-hydroxypiperidine

CAS: 143900-44-1

Formula: C₁₀H₁₉NO₃

Purity: >98.0%(GC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 201.27

Ref: 3B-B4446

(S)-1-Boc-3-hydroxypiperidine, 97%

CAS: 143900-44-1

(S)-1-Boc-3-hydroxypiperidine is used as pharmaceutical intermediate. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU re

Formula: C₁₀H₁₉NO₃

Purity: 97%

Color and Shape: White to off-white, Solid

Molecular weight: 201.27

Ref: 02-H52771

(S)-1-Boc-3-Hydroxypiperidine

CAS: 143900-44-1

Formula: C₁₀H₁₉NO₃

Purity: 96%

Color and Shape: Solid

Molecular weight: 201.2628

Ref: IN-DA0032GJ

(3S)-3-Hydroxypiperidine, N-BOC protected

CAS: 143900-44-1

(3S)-3-Hydroxypiperidine, N-BOC protected

Formula: C₁₀H₁₉NO₃

Purity: 98%

Color and Shape: white to off-white. crystalline solid

Molecular weight: 201.26g/mol

Ref: 54-OR4581

Ibrutinib Interm 0441

CAS: 143900-44-1

Ibrutinib Interm 0441 is a piperidine derivative with an amine protecting group and may be used in the preparation of biologically active compounds.

Formula: C₁₀H₁₉NO₃

Color and Shape: Solid

Molecular weight: 201.26

Ref: TM-T21357

Ibrutinib Impurity 7

CAS: 143900-44-1

Formula: C₁₀H₁₉NO₃

Molecular weight: 201.27

Ref: 4Z-I-061010

(S)-1-Boc-3-hydroxypiperidine

Controlled Product

CAS: 143900-44-1

Applications (S)-1-Boc-3-hydroxypiperidine is an important chiral intermediate for the synthesis of ibrutinib, an anticancer drug targeting B-cell malignancies. Synthesis of pharmaceutical intermediates including ibrutinib, the API of the newly approved drug Imbruvica, for the treatment of lymphoma.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Chen, L., et al.: Tetrahedron Lett., 58, 1644 (2017); Ju, X., et al.: Org. Process Res. Dev., 18, 827 (2014)

Formula: C₁₀H₁₉NO₃

Color and Shape: Neat

Molecular weight: 201.26

Ref: TR-B656650

(S)-1-Boc-3-hydroxypiperidine

CAS: 143900-44-1

Intermediate in the synthesis of ibrutinib

Formula: C₁₀H₁₉NO₃

Purity: Min. 97 Area-%

Color and Shape: White Powder

Molecular weight: 201.26 g/mol

Ref: 3D-FB15323

(S)-1-N-Boc-3-Hydroxypiperidine

CAS: 143900-44-1

Formula: C₁₀H₁₉NO₃

Purity: 96%

Color and Shape: Solid, Crystalline Powder

Molecular weight: 201.266

Ref: 10-F034257

(S)-1-Boc-3-hydroxypiperidine-d4

Controlled Product

CAS: 143900-44-1

Applications (S)-1-Boc-3-hydroxypiperidine-d4 is an intermediate in synthesizing Ibrutinib-d4 (I124971), a labelled analogue of Ibrutinib (I124970). Ibrutinib is a highly selective Bruton’s tyrosine kinase (Btk) irreversible inhibitor.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References MacGlashan, D., et. al.: Int. Immunol., 11, 475 (2011)

Formula: C₁₀D₄H₁₅NO₃

Color and Shape: Neat

Molecular weight: 205.287

Ref: TR-B656652

Ibrutinib Impurity 15

CAS: 143900-44-1

Formula: C₁₀H₁₉NO₃

Molecular weight: 201.27

Ref: ST-EA-CP-I20034