CAS 144-11-6: (±)-Trihexyphenidyl

Description: (±)-Trihexyphenidyl is a synthetic anticholinergic medication primarily used to treat Parkinson's disease and drug-induced extrapyramidal symptoms. It functions by blocking the action of acetylcholine at muscarinic receptors, which helps to alleviate symptoms such as tremors and rigidity. The compound is characterized by its chemical structure, which includes a phenyl ring and a piperidine moiety, contributing to its pharmacological activity. It is typically administered orally and has a relatively long half-life, allowing for once or twice daily dosing. The substance is known for its potential side effects, which may include dry mouth, blurred vision, constipation, and urinary retention, due to its anticholinergic properties. Additionally, (±)-Trihexyphenidyl is classified as a controlled substance in some jurisdictions due to its potential for misuse and side effects. Its efficacy and safety profile make it a valuable option in the management of movement disorders, although careful monitoring is essential to mitigate adverse effects.

Formula: C₂₀H₃₁NO

InChI: InChI=1S/C20H31NO/c22-20(18-10-4-1-5-11-18,19-12-6-2-7-13-19)14-17-21-15-8-3-9-16-21/h1,4-5,10-11,19,22H,2-3,6-9,12-17H2

InChI key: InChIKey=HWHLPVGTWGOCJO-UHFFFAOYSA-N

SMILES: OC(C=1C=CC=CC1)(CCN2CCCCC2)C3CCCCC3

Synonyms:

• (.+-.)-Triphenidyl
• 1-Cyclohexyl-1-Phenyl-3-(1-Piperidyl)Propan-1-Ol
• 1-Cyclohexyl-1-Phenyl-3-(Piperidin-1-Yl)Propan-1-Ol
• 1-Cyclohexyl-1-phenyl-3-piperidin-1-ylpropan-1-ol
• 1-Piperidinepropanol, α-cyclohexyl-α-phenyl-
• Benzhexol
• Nsc 12268
• Trihexifenidilo
• Trihexyphenidyl
• Trihexyphenidyle
• α-Cyclohexyl-α-phenyl-1-piperidinepropanol

Trihexyphenidyl Hydrochloride

CAS: 144-11-652-49-3

• Formula: C₂₀H₃₁NO·HCl
• Purity: >98.0%(T)(HPLC)
• Color and Shape: White to Almost white powder to crystal
• Molecular weight: 337.93

1-Piperidinepropanol, α-cyclohexyl-α-phenyl-

CAS: 144-11-6

• Formula: C₂₀H₃₁NO
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 301.4662

D,L-Trihexyphenidyl Hydrochloride-D11

CAS: 144-11-652-49-3

• Formula: C₂₀H₂₁D₁₁ClNO
• Color and Shape: Off White Solid
• Molecular weight: 348.99