CAS 144035-83-6: Piclamilast

Description: Piclamilast, with the CAS number 144035-83-6, is a selective phosphodiesterase-4 (PDE4) inhibitor primarily investigated for its potential therapeutic applications in treating inflammatory diseases, particularly asthma and chronic obstructive pulmonary disease (COPD). As a small organic molecule, it exhibits anti-inflammatory properties by increasing intracellular levels of cyclic adenosine monophosphate (cAMP), which subsequently modulates various cellular responses involved in inflammation. Piclamilast is characterized by its ability to reduce the production of pro-inflammatory cytokines and inhibit the activation of immune cells, thereby contributing to its therapeutic effects. The compound is typically administered orally and has been studied for its pharmacokinetic profile, which includes absorption, distribution, metabolism, and excretion characteristics. While it shows promise in clinical settings, potential side effects may include gastrointestinal disturbances and headache, which are common with PDE4 inhibitors. Overall, Piclamilast represents a significant area of research in the development of targeted therapies for chronic inflammatory conditions.

Formula: C₁₈H₁₈Cl₂N₂O₃

InChI: InChI=1S/C18H18Cl2N2O3/c1-24-15-7-6-11(8-16(15)25-12-4-2-3-5-12)18(23)22-17-13(19)9-21-10-14(17)20/h6-10,12H,2-5H2,1H3,(H,21,22,23)

InChI key: InChIKey=RRRUXBQSQLKHEL-UHFFFAOYSA-N

SMILES: O=C(NC=1C(Cl)=CN=CC1Cl)C2=CC=C(OC)C(OC3CCCC3)=C2

Synonyms:

• 3-(Cyclopentyloxy)-N-(3,5-dichloro-4-pyridinyl)-4-methoxybenzamide
• 3-(Cyclopentyloxy)-N-(3,5-dichloro-4-pyridyl)-p-anisamide
• 3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-methoxybenzamide
• Benzamide, 3-(cyclopentyloxy)-N-(3,5-dichloro-4-pyridinyl)-4-methoxy-
• Ccris 8304
• Cpodpmb
• N-(3,5-Dichloropyrid-4-yl)-3-cyclopentyloxy-4-methoxybenzamide
• Piclamilast
• Piclamilast [INN]
• Rp 73401
• Rpr 73401
• 3-(Cyclopentyloxy)-N-(3,5-dichloro-4-pyridyl)-4-methoxybenzamide

3-(cyclopentyloxy)-N-(3,5-dichloro-4-pyridyl)-4-methoxybenzamide

CAS: 144035-83-6

• Formula: C₁₈H₁₈Cl₂N₂O₃
• Purity: 99%
• Molecular weight: 381.2531199999999

Piclamilast

CAS: 144035-83-6

• Purity: 98.28%
• Molecular weight: 381.25g/mol

Piclamilast

CAS: 144035-83-6

Piclamilast (RP 73401) is a PDE4 inhibitor.

• Formula: C₁₈H₁₈Cl₂N₂O₃
• Purity: 98.28%
• Color and Shape: Solid
• Molecular weight: 381.25

Piclamilast

CAS: 144035-83-6

Versatile small molecule scaffold

• Formula: C₁₈H₁₈Cl₂N₂O₃
• Purity: Min. 95%
• Molecular weight: 381.25 g/mol