CAS 144035-83-6

Piclamilast

Description:

Piclamilast, with the CAS number 144035-83-6, is a selective phosphodiesterase-4 (PDE4) inhibitor primarily investigated for its potential therapeutic applications in treating inflammatory diseases, particularly asthma and chronic obstructive pulmonary disease (COPD). As a small organic molecule, it exhibits anti-inflammatory properties by increasing intracellular levels of cyclic adenosine monophosphate (cAMP), which subsequently modulates various cellular responses involved in inflammation. Piclamilast is characterized by its ability to reduce the production of pro-inflammatory cytokines and inhibit the activation of immune cells, thereby contributing to its therapeutic effects. The compound is typically administered orally and has been studied for its pharmacokinetic profile, which includes absorption, distribution, metabolism, and excretion characteristics. While it shows promise in clinical settings, potential side effects may include gastrointestinal disturbances and headache, which are common with PDE4 inhibitors. Overall, Piclamilast represents a significant area of research in the development of targeted therapies for chronic inflammatory conditions.

Formula: C₁₈H₁₈Cl₂N₂O₃

InChI: InChI=1S/C18H18Cl2N2O3/c1-24-15-7-6-11(8-16(15)25-12-4-2-3-5-12)18(23)22-17-13(19)9-21-10-14(17)20/h6-10,12H,2-5H2,1H3,(H,21,22,23)

InChI key: InChIKey=RRRUXBQSQLKHEL-UHFFFAOYSA-N

SMILES: O(C1=C(OC)C=CC(C(NC=2C(Cl)=CN=CC2Cl)=O)=C1)C3CCCC3

Synonyms:

• 3-(Cyclopentyloxy)-N-(3,5-dichloro-4-pyridinyl)-4-methoxybenzamide
• 3-(Cyclopentyloxy)-N-(3,5-dichloro-4-pyridyl)-p-anisamide
• 3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-methoxybenzamide
• Benzamide, 3-(cyclopentyloxy)-N-(3,5-dichloro-4-pyridinyl)-4-methoxy-
• Ccris 8304
• Cpodpmb
• N-(3,5-Dichloropyrid-4-yl)-3-cyclopentyloxy-4-methoxybenzamide
• Piclamilast
• Piclamilast [INN]
• Rp 73401
• Rpr 73401

3-(cyclopentyloxy)-N-(3,5-dichloro-4-pyridyl)-4-methoxybenzamide

CAS: 144035-83-6

Formula: C₁₈H₁₈Cl₂N₂O₃

Purity: 99%

Molecular weight: 381.2531

Ref: IN-DA00AE4S

Piclamilast

CAS: 144035-83-6

Piclamilast

Purity: ≥98%

Molecular weight: 381.25g/mol

Ref: 54-BUP03849

Piclamilast

CAS: 144035-83-6

Piclamilast (RP 73401) is a PDE4 inhibitor.

Formula: C₁₈H₁₈Cl₂N₂O₃

Purity: 98.28% - 99.57%

Color and Shape: Solid

Molecular weight: 381.25

Ref: TM-T23154

Piclamilast

CAS: 144035-83-6

Piclamilast is a selective phosphodiesterase-4 (PDE4) inhibitor, which is a compound derived from synthetic sources. Its primary mode of action involves the inhibition of the PDE4 enzyme, leading to an increase in intracellular cyclic adenosine monophosphate (cAMP) levels. This elevation of cAMP results in the downregulation of proinflammatory cytokine production and the modulation of inflammatory cell response, thereby exerting potent anti-inflammatory effects.In the realm of clinical applications, Piclamilast is investigated for its potential in the treatment of inflammatory conditions such as asthma and chronic obstructive pulmonary disease (COPD). Its capability to modulate immune response mechanisms underscores its therapeutic promise in respiratory and possibly other inflammatory diseases. Through extensive research and trials, Piclamilast continues to be a compound of interest, warranting further exploration to fully elucidate its pharmacokinetic properties and broader spectrum of efficacy across various inflammatory disorders.

Formula: C₁₈H₁₈Cl₂N₂O₃

Purity: Min. 95%

Molecular weight: 381.25 g/mol

Ref: 3D-UFA03583