CAS 144089-98-5

2′-Deoxy-2′-[(2,2,2-trifluoroacetyl)amino]guanosine

Description:

2′-Deoxy-2′-[(2,2,2-trifluoroacetyl)amino]guanosine is a modified nucleoside that features a guanine base linked to a deoxyribose sugar, with a trifluoroacetyl group attached to the amino position. This modification enhances its chemical stability and can influence its interactions in biological systems. The trifluoroacetyl group is known for its electron-withdrawing properties, which can affect the nucleoside's reactivity and binding affinity to other molecules, such as enzymes or nucleic acids. The presence of fluorine atoms can also impart unique characteristics, such as increased lipophilicity and altered hydrogen bonding capabilities. This compound is often utilized in biochemical research, particularly in studies involving nucleic acid synthesis and modification, as well as in the development of antiviral and anticancer agents. Its specific structural features make it a valuable tool for probing the mechanisms of nucleic acid interactions and for designing novel therapeutic agents.

Formula: C₁₂H₁₃F₃N₆O₅

InChI: InChI=1S/C12H13F3N6O5/c13-12(14,15)10(25)18-4-6(23)3(1-22)26-9(4)21-2-17-5-7(21)19-11(16)20-8(5)24/h2-4,6,9,22-23H,1H2,(H,18,25)(H3,16,19,20,24)/t3-,4-,6-,9-/m1/s1

InChI key: InChIKey=DWVVZCNIKDWTEY-DXTOWSMRSA-N

SMILES: N(C(C(F)(F)F)=O)[C@H]1[C@H](N2C3=C(N=C2)C(=O)N=C(N)N3)O[C@H](CO)[C@H]1O

Synonyms:

• Guanosine, 2′-deoxy-2′-[(2,2,2-trifluoroacetyl)amino]-
• 2′-Deoxy-2′-[(2,2,2-trifluoroacetyl)amino]guanosine
• Guanosine, 2′-deoxy-2′-[(trifluoroacetyl)amino]-

2'-TFA-NH-dG

CAS: 144089-98-5

Formula: C₁₂H₁₃F₃N₆O₅

Molecular weight: 378.2640

Ref: IN-DA001IWK

2'-TFA-NH-dG

CAS: 144089-98-5

2'-TFA-NH-dG is a novel nucleoside analog that is used as an antiviral and anticancer agent. It is a synthetic monophosphate with a modified 2'-hydroxyl group and a deoxyribose sugar backbone. It has been shown to inhibit HIV replication in vitro by interfering with the synthesis of viral DNA and RNA, which may be due to its ability to bind to the viral reverse transcriptase enzyme. 2'-TFA-NH-dG has also been shown to have anticancer activity against human A549 cells in vitro by inhibiting the proliferation of these cells. This drug is available for purchase as a white powder at CAS No. 144089-98-5.

Formula: C₁₂H₁₃F₃N₆O₅

Purity: Min. 95%

Molecular weight: 378.26 g/mol

Ref: 3D-NT57541