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CAS 1441-87-8

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2-Hydroxybenzoyl chloride

Description:
2-Hydroxybenzoyl chloride, also known as salicyloyl chloride, is an organic compound characterized by the presence of both a hydroxyl group and an acyl chloride functional group. Its molecular structure features a benzene ring with a hydroxyl (-OH) group positioned ortho to a carbonyl chloride (-C(=O)Cl) group. This compound is typically a colorless to pale yellow liquid with a pungent odor, and it is known for its reactivity, particularly in acylation reactions. 2-Hydroxybenzoyl chloride is soluble in organic solvents such as dichloromethane and ether but is generally insoluble in water due to its hydrophobic aromatic structure. It is often used as an intermediate in the synthesis of various pharmaceuticals, agrochemicals, and dyes. Due to the presence of the acyl chloride group, it can react vigorously with water, alcohols, and amines, releasing hydrochloric acid, which necessitates careful handling and storage under anhydrous conditions. Safety precautions are essential when working with this compound due to its corrosive nature and potential to cause skin and respiratory irritation.
Formula:C7H5ClO2
InChI:InChI=1/C7H5ClO2/c8-7(10)5-3-1-2-4-6(5)9/h1-4,9H
InChI key:InChIKey=DVIHKVWYFXLBEM-UHFFFAOYSA-N
SMILES:C(Cl)(=O)C1=C(O)C=CC=C1
Synonyms:
  • Benzoyl chloride, 2-hydroxy-
  • 2-Hydroxybenzoyl chloride
  • Salicyl chloride
  • Salicyloyl chloride
  • o-Hydroxybenzoyl chloride
  • 2-Hydroxy-Benzoyl Chloride
  • Benzoyl chloride, 2-hydroxy- (9CI)
  • Sildenafil Impurity 151
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