CAS 144161-76-2

arginyl-glycyl-aspartyl-tryptophan

Description:

Arginyl-glycyl-aspartyl-tryptophan, often abbreviated as RGDT, is a synthetic peptide composed of four amino acids: arginine, glycine, aspartic acid, and tryptophan. This peptide is notable for its role in cell adhesion and signaling, particularly in the context of biomaterials and tissue engineering. The presence of arginine and aspartic acid contributes to its ability to interact with cell surface receptors, promoting cell attachment and proliferation. Tryptophan, with its aromatic side chain, can influence the peptide's structural properties and stability. RGDT is often studied for its potential applications in drug delivery systems and regenerative medicine, where enhancing cellular interactions is crucial. The peptide's sequence and composition allow it to mimic natural extracellular matrix components, making it a valuable tool in biochemistry and molecular biology research. Its CAS number, 144161-76-2, serves as a unique identifier for regulatory and commercial purposes, facilitating its use in various scientific applications.

Formula: C₂₃H₃₂N₈O₇

InChI: InChI=1/C23H32N8O7/c24-14(5-3-7-27-23(25)26)20(35)29-11-18(32)30-16(9-19(33)34)21(36)31-17(22(37)38)8-12-10-28-15-6-2-1-4-13(12)15/h1-2,4,6,10,14,16-17,28H,3,5,7-9,11,24H2,(H,29,35)(H,30,32)(H,31,36)(H,33,34)(H,37,38)(H4,25,26,27)/t14-,16-,17-/m0/s1

SMILES: c1ccc2c(c1)c(C[C@@H](C(=O)O)N=C([C@H](CC(=O)O)N=C(CN=C([C@H](CCCNC(=N)N)N)O)O)O)c[nH]2

Synonyms:

• D-Arg-gly-asp-trp
• D-Rgdw
• dRGDW
• L-Tryptophan, N-(N-(N-D-arginylglycyl)-L-alpha-aspartyl)-
• N~5~-(diaminomethylidene)-L-ornithylglycyl-L-alpha-aspartyl-L-tryptophan

H-D-Arg-Gly-Asp-Trp-OH

CAS: 144161-76-2

H-D-Arg-Gly-Asp-Trp-OH is a cyclic peptide that has been shown to bind to staphylococcal cells, inhibiting their growth. The peptide was found to have proton binding and membrane interactions. This drug has shown efficacy in biological samples such as collagen and fibrinogen. H-D-Arg-Gly-Asp-Trp-OH also can be activated by a disulfide bond. It has been found to bind with monoclonal antibodies and model systems.

Formula: C₂₃H₃₂N₈O₇

Purity: Min. 95%

Molecular weight: 532.55 g/mol

Ref: 3D-FA108978