CAS 1443235-95-7

JAK3-IN-6

Description:

JAK3-IN-6, identified by its CAS number 1443235-95-7, is a small molecule inhibitor specifically targeting Janus kinase 3 (JAK3), which plays a crucial role in the signaling pathways of various cytokines and growth factors. This compound is primarily studied for its potential therapeutic applications in autoimmune diseases and certain types of cancers, where JAK3 is implicated in aberrant signaling. Characteristically, JAK3-IN-6 exhibits selective inhibition, which is essential for minimizing off-target effects and enhancing its efficacy in clinical settings. The compound's structure typically includes functional groups that facilitate its interaction with the JAK3 enzyme, leading to a reduction in its activity. Additionally, JAK3-IN-6 is often evaluated for its pharmacokinetic properties, including absorption, distribution, metabolism, and excretion (ADME), to determine its suitability for further development as a therapeutic agent. Overall, JAK3-IN-6 represents a promising candidate in the field of targeted therapies, particularly for conditions associated with dysregulated JAK3 activity.

Formula: C₁₉H₁₈N₄O₃

Synonyms:

• 7H-Pyrrolo[2,3-d]pyrimidine-5-carboxylic acid, 4-[3-[(2-methyl-1-oxo-2-propen-1-yl)amino]phenyl]-, ethyl ester
• SelectiveJAK3inhibitor1
• JAK3-IN-6
• JAK3-IN-2
• (JAK3 inhibitor 2)
• ethyl 4-{3-[(2-methylacryloyl)amino]phenyl}-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylate
• JAK3-IN-6 (Compound 2)
• JAK3 inhibitor 6

JAK3-IN-6

CAS: 1443235-95-7

Formula: C₁₉H₁₈N₄O₃

Purity: 99%

Molecular weight: 350.3712

Ref: IN-DA01FTS8

Ethyl 4-(3-Methacrylamidophenyl)-7H-Pyrrolo[2,3-D]Pyrimidine-5-Carboxylate

CAS: 1443235-95-7

Ethyl 4-(3-Methacrylamidophenyl)-7H-Pyrrolo[2,3-D]Pyrimidine-5-Carboxylate

Purity: 98%

Molecular weight: 350.37g/mol

Ref: 54-OR1023045

JAK3-IN-6

CAS: 1443235-95-7

JAK3-IN-6

Purity: ≥95%

Molecular weight: 350.37g/mol

Ref: 54-BUP13061

JAK3-IN-6

CAS: 1443235-95-7

JAK3-IN-6 is irreversible Janus Associated Kinase 3 (JAK3) inhibitor, with an IC50 of 0.15 nM

Formula: C₁₉H₁₈N₄O₃

Purity: 99.94% - 99.94%

Color and Shape: Solid

Molecular weight: 350.37

Ref: TM-T5492

JAK3-IN-6

CAS: 1443235-95-7

Jak3-IN-6 is a protein that has been shown to be involved in the assembly of the nephron, which is a functional unit of the kidney. It also appears to play a role in the connector module and sequence antenna. The Jak3-IN-6 gene encodes a protein that inhibits GSK3β, an inhibitory factor that regulates organ development. This protein may be involved in the process of heparin binding, which is thought to have anti-leukemia properties. Jak3-IN-6 may also be associated with leukemia and GSK3β inhibition.

Formula: C₁₉H₁₈N₄O₃

Purity: Min. 95%

Molecular weight: 350.37 g/mol

Ref: 3D-THC23595