CAS 144334-59-8

2-FLUORO-5-HYDROXY-L-TYROSINE HYDROCHLORIDE

Description:

2-Fluoro-5-hydroxy-L-tyrosine hydrochloride is a derivative of the amino acid tyrosine, characterized by the presence of a fluorine atom at the 2-position and a hydroxyl group at the 5-position of the aromatic ring. This compound is typically a white to off-white crystalline solid, soluble in water and polar organic solvents, which is indicative of its polar functional groups. The presence of the hydroxyl group contributes to its potential for hydrogen bonding, influencing its reactivity and interactions in biological systems. As a hydrochloride salt, it is often more stable and easier to handle than its free base form. This compound may be of interest in biochemical research, particularly in studies related to neurotransmitter synthesis, as tyrosine is a precursor to several important neurotransmitters. Additionally, the introduction of fluorine can modify the biological activity and pharmacokinetics of the molecule, making it a subject of interest in medicinal chemistry. Safety data should be consulted for handling and usage, as with any chemical substance.

Formula: C₉H₁₁ClFNO₄

Synonyms:

• L-Tyrosine, 2-Fluoro-5-Hydroxy-, Hydrochloride
• 6-Fluoro-L-Dopa Hydrochloride
• 6-Fluoro-Dopa Hydrochloride
• F-L-DOPA?Cl

Levodopa Impurity 10 HCl

CAS: 144334-59-8

Formula: C₉H₁₀FNO₄·HCl

Molecular weight: 215.18 36.46

Ref: 4Z-D-32110

2-Fluoro-5-hydroxyl-L-tyrosine hydrochloride

CAS: 144334-59-8

2-Fluoro-5-hydroxyl-L-tyrosine HCl is a radiopharmaceutical that is used as a radiotracer for positron emission tomography (PET) imaging of cancer. It is synthesized by reaction of 2-fluoro-5-(2,2,2,-trifluoroethyl)phenol with L-tyrosine in acid medium. The solvent and impurities are removed by preparative high performance liquid chromatography (HPLC). Radiochemical purity is determined by analytical HPLC, and the radiopharmaceutical is characterized by nuclear magnetic resonance (NMR), mass spectrometry, and infrared spectroscopy. The radiotracer has been validated for use in humans and animals in clinical trials. It has been shown to be more efficient than other analogues such as diaryliodonium chloride or on-line coupling agents.

Formula: C₉H₁₀FNO₄•HCl

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 251.64 g/mol

Ref: 3D-FF14262