CAS 14439-61-3

Ro 5-4864

Description:

Ro 5-4864, also known by its chemical name, is a selective antagonist of the sigma-1 receptor, which is a protein involved in various neurobiological processes. This compound is characterized by its ability to modulate neurotransmitter release and has been studied for its potential therapeutic effects in conditions such as depression, anxiety, and neurodegenerative diseases. Ro 5-4864 exhibits a relatively high affinity for sigma-1 receptors compared to other receptor types, making it a valuable tool in pharmacological research. Its chemical structure includes specific functional groups that contribute to its receptor binding properties. Additionally, Ro 5-4864 has been investigated for its role in enhancing cognitive function and neuroprotection, although further research is needed to fully understand its mechanisms and potential clinical applications. As with many pharmacological agents, the safety profile and side effects of Ro 5-4864 are important considerations in its development and use in research settings.

Formula: C₁₆H₁₂Cl₂N₂O

InChI: InChI=1S/C16H12Cl2N2O/c1-20-14-7-6-12(18)8-13(14)16(19-9-15(20)21)10-2-4-11(17)5-3-10/h2-8H,9H2,1H3

InChI key: InChIKey=PUMYFTJOWAJIKF-UHFFFAOYSA-N

SMILES: CN1C=2C(C(=NCC1=O)C3=CC=C(Cl)C=C3)=CC(Cl)=CC2

Synonyms:

• 2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(4-chlorophenyl)-1,3-dihydro-1-methyl-
• 2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(p-chlorophenyl)-1,3-dihydro-1-methyl-
• 4-Chlorodiazepam
• 7-Chloro-1-methyl-5-(p-chlorophenyl)-3H-1,4-benzodiazepin-2(1H)-one
• 7-Chloro-5-(4-chlorophenyl)-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-one
• 7-chloro-5-(4-chlorophenyl)-1-methyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one
• Chlordiazepam
• Ro 05-4864
• Ro 5-4864

2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(4-chlorophenyl)-1,3-dihydro-1-methyl-

CAS: 14439-61-3

Formula: C₁₆H₁₂Cl₂N₂O

Purity: 95%

Color and Shape: Solid

Molecular weight: 319.1853

Ref: IN-DA001JG4

4'-Chlorodiazepam

Controlled Product

CAS: 14439-61-3

Applications 4'-Chlorodiazepam has anxiogenic activity.
References Pellow, S., et al.: Pharmacol. Biochem. Behavior, 24, 525 (1986);

Formula: C₁₆H₁₂Cl₂N₂O

Color and Shape: Neat

Molecular weight: 319.19

Ref: TR-C366833

4'-Chlorodiazepam-13CD3

Controlled Product

CAS: 14439-61-3

Formula: CC₁₅D₃H₉Cl₂N₂O

Color and Shape: Neat

Molecular weight: 323.196

Ref: TR-C366834

4'-Chlorodiazepam

Controlled Product

CAS: 14439-61-3

4²-Chlorodiazepam is an ester of 4-chloro-diazepam, which is a benzodiazepine. It has been shown to inhibit the mitochondrial membrane potential, voltage-dependent calcium channels, and intracellular Ca2+ levels in a variety of experimental models. This inhibition leads to decreased Ca2+ entry into the mitochondria and impaired mitochondrial functions. 4²-Chlorodiazepam has also been shown to have a protective effect on brain cells by inhibiting oxidative stress and protecting against glutamate toxicity. In addition, this drug inhibits histone deacetylase activity and promotes cell cycle arrest at the G0/G1 phase. The constant pressure experimental model has demonstrated that 4²-chlorodiazepam can be used as an effective antimicrobial agent against microorganisms such as Escherichia coli, Staphylococcus aureus, Salmonella typhimurium, Streptococcus pyogenes, Pseud

Formula: C₁₆H₁₂Cl₂N₂O

Purity: Min. 95%

Molecular weight: 319.19 g/mol

Ref: 3D-PAA43961