CAS 144409-99-4

amyloid B-protein

Description:

Amyloid beta-protein (Aβ) is a peptide primarily associated with Alzheimer's disease and is derived from the amyloid precursor protein (APP). It typically consists of 36 to 43 amino acids, with the most common forms being Aβ40 and Aβ42. The protein is characterized by its propensity to misfold and aggregate into insoluble fibrils, which are a hallmark of amyloid plaques found in the brains of Alzheimer's patients. These aggregates can disrupt cell function and trigger neuroinflammation. Aβ is hydrophobic, which contributes to its aggregation properties, and it can form various oligomeric species that are believed to be neurotoxic. The peptide's structure includes a central hydrophobic region that facilitates its aggregation, and it can adopt different conformations, including alpha-helical and beta-sheet structures. Research into Aβ focuses on understanding its role in neurodegeneration and exploring potential therapeutic strategies to inhibit its aggregation or promote its clearance from the brain.

Formula: C₁₉₄H₂₉₅N₅₃O₅₈S

Synonyms:

• Amyloid .beta.-Protein (40-1)
• H-Val-Val-Gly-Gly-Val-Met-Leu-Gly-Ile-Ile-Ala-Gly-Lys-Asn-Ser-Gly-Val-Asp-Glu-Ala-Phe-Phe-Val-Leu-Lys-Gln-His-His-Val-Glu-Tyr-Gly-Ser-Asp-His-Arg-Phe-Glu-Ala-Asp-OH

Amyloid β-Protein (40-1)

CAS: 144409-99-4

Reverse sequence of Aβ 1-40. Inactive control for Aβ40.

Formula: C₁₉₄H₂₉₅N₅₃O₅₈S

Purity: 93.6%

Color and Shape: White Powder

Molecular weight: 4329.86

Ref: 01-4030203

Amyloid β-Protein (40-1) hydrochloride salt

CAS: 144409-99-4

Hydrochloride salt

Formula: C₁₉₄H₂₉₅N₅₃O₅₈S

Purity: Min. 95%

Molecular weight: 4,329.81 g/mol

Ref: 3D-FA110238

Amyloid β-Protein (40-1)

CAS: 144409-99-4

Amyloid Beta-Protein (40-1) is a peptide that is found in the brain, and is thought to be involved in Alzheimer’s disease. Amyloid Beta-Protein (40-1) has been shown to inhibit protein interactions and activator functions, as well as act as a ligand for receptors. This protein can be used as a research tool for studying ion channels and antibodies. It also has high purity and can be used for life science experiments.

Formula: C₁₉₄H₂₉₅N₅₃O₅₈S

Purity: Min. 95%

Molecular weight: 4,329.8 g/mol

Ref: 3D-PAB-4413-S

Amyloid β-Protein (40-1) trifluoroacetate salt

CAS: 144409-99-4

Trifluoroacetate salt

Formula: C₁₉₄H₂₉₅N₅₃O₅₈S

Purity: Min. 95%

Molecular weight: 4,329.81 g/mol

Ref: 3D-FA108830