CAS 144457-28-3

CLOPIDOGREL CARBOXYLIC ACID

Description:

Clopidogrel carboxylic acid, with the CAS number 144457-28-3, is a chemical compound that serves as a key metabolite of clopidogrel, an antiplatelet medication widely used to prevent blood clots. This substance is characterized by its carboxylic acid functional group, which contributes to its solubility and reactivity. Clopidogrel carboxylic acid is typically a white to off-white solid, and it exhibits moderate stability under standard conditions. Its molecular structure includes a thiophene ring, which is essential for its biological activity. The compound is known for its role in inhibiting platelet aggregation by blocking the ADP receptor, thereby reducing the risk of thrombotic events. In terms of pharmacokinetics, clopidogrel carboxylic acid is primarily formed in the liver through metabolic processes, and its efficacy is influenced by genetic variations in metabolic enzymes. Overall, clopidogrel carboxylic acid is significant in the context of cardiovascular therapy and pharmacology.

Formula: C₁₅H₁₄ClNO₂S

InChI: InChI=1/C15H14ClNO2S/c16-12-4-2-1-3-11(12)14(15(18)19)17-7-5-13-10(9-17)6-8-20-13/h1-4,6,8,14H,5,7,9H2,(H,18,19)

SMILES: c1ccc(c(c1)C(C(=O)O)N1CCc2c(ccs2)C1)Cl

Synonyms:

• (S)-α-(2-Chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5
• (4H)-acetic Acid
• [(+)-(S)-(o-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-acetic acid
• (2-chlorophenyl)(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetic acid
• (S)-α-(2-Chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-acetic Acid
• ((S)-Clopidogrel Carboxylic Acid)
• Clopidogrel Related Compound A
• (S)-2-(2-Chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetic acid
• Clopidogrel Carboxylic Acid Discontinued See C587235
• SR 26334
• (S)-Clopidogrel Carboxylic Acid (Clopidogrel Related CoMpound A)

Thieno[3,2-c]pyridine-5(4H)-acetic acid, α-(2-chlorophenyl)-6,7-dihydro-, (αS)-

CAS: 144457-28-3

Formula: C₁₅H₁₄ClNO₂S

Purity: 98%

Color and Shape: Solid

Molecular weight: 307.7952

Ref: IN-DA001JKA

Clopidogrel carboxylic acid

CAS: 144457-28-3

Clopidogrel Related Compound A is a useful organic compound for research related to life sciences.

Formula: C₁₅H₁₄ClNO₂S

Color and Shape: Solid

Molecular weight: 307.79

Ref: TM-T125853

Clopidogrel EP Impurity A ((S)-Clopidogrel Carboxylic Acid)

CAS: 144457-28-3

Formula: C₁₅H₁₄ClNO₂S

Color and Shape: Off-White Solid

Molecular weight: 307.79

Ref: 4Z-C-1321

Clopidogrel EP Impurity A

CAS: 144457-28-3

Formula: C₁₅H₁₄ClNO₂S

Molecular weight: 307.80

Ref: ST-EA-CP-C2001

Clopidogrel carboxylic acid

CAS: 144457-28-3

Clopidogrel is a potent inhibitor of the platelet aggregation. It reduces blood clotting by inhibiting the ADP receptor on the surface of platelets, thereby inhibiting the aggregation and adhesion of platelets. Clopidogrel has been shown to be effective in preventing thrombosis, myocardial infarction (heart attack), and stroke. Clopidogrel inhibits the activity of cytochrome P450 3A4 (CYP3A4) and p2Y 12 receptors. Clopidogrel has been shown to have synergic effects with nonsteroidal anti-inflammatory drugs (NSAIDs). The polymorphic nature of Clopidogrel can be monitored using a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for quantification in biological samples such as human serum and plasma.

Formula: C₁₅H₁₄ClNO₂S

Purity: Min. 95%

Molecular weight: 307.8 g/mol

Ref: 3D-FC20510