CAS 144459-70-1

Rofleponide

Description:

Rofleponide is a synthetic corticosteroid primarily used for its anti-inflammatory and immunosuppressive properties. It is characterized by its ability to modulate the immune response and reduce inflammation, making it beneficial in treating various inflammatory conditions. The compound exhibits high affinity for glucocorticoid receptors, which contributes to its efficacy in managing diseases such as asthma and allergic rhinitis. Rofleponide is typically administered via inhalation, allowing for localized effects in the respiratory system while minimizing systemic side effects. Its pharmacokinetic profile includes rapid absorption and metabolism, leading to a relatively short half-life. The substance is known for its favorable safety profile compared to other corticosteroids, with a lower incidence of systemic side effects. However, like all corticosteroids, it may still pose risks of local irritation or potential suppression of the hypothalamic-pituitary-adrenal (HPA) axis with prolonged use. Overall, Rofleponide represents a valuable option in the therapeutic arsenal for managing chronic inflammatory diseases.

Formula: C₂₅H₃₄F₂O₆

InChI: InChI=1S/C25H34F2O6/c1-4-5-21-32-20-10-14-15-9-17(26)16-8-13(29)6-7-22(16,2)24(15,27)18(30)11-23(14,3)25(20,33-21)19(31)12-28/h8,14-15,17-18,20-21,28,30H,4-7,9-12H2,1-3H3/t14-,15-,17-,18-,20+,21+,22-,23-,24-,25+/m0/s1

InChI key: InChIKey=IXTCZMJQGGONPY-XJAYAHQCSA-N

SMILES: C(CO)(=O)[C@]12[C@]3(C)[C@@](C[C@]1(O[C@@H](CCC)O2)[H])([C@]4([C@](F)([C@@H](O)C3)[C@]5(C)C([C@@H](F)C4)=CC(=O)CC5)[H])[H]

Synonyms:

• Pregn-4-ene-3,20-dione, 16,17-[(1R)-butylidenebis(oxy)]-6,9-difluoro-11,21-dihydroxy-, (6α,11β,16α)-
• Pregn-4-ene-3,20-dione, 16,17-[butylidenebis(oxy)]-6,9-difluoro-11,21-dihydroxy-, [6α,11β,16α(R)]-
• Rofleponide
• 6α,9-Difluoro-11β,16α,17,21-tetrahydroxypregn-4-ene-3,20-dione, cyclic (R)-16,17-acetal with butyraldehyde
• (6α,11β,16α)-16,17-[(1R)-Butylidenebis(oxy)]-6,9-difluoro-11,21-dihydroxypregn-4-ene-3,20-dione

Rofleponide

CAS: 144459-70-1

Rofleponide

Purity: ≥98%

Molecular weight: 468.53g/mol

Ref: 54-BUP07395

Rofleponide

CAS: 144459-70-1

Rofleponide is a synthetic glucocorticosteroid with a high affinity for the rat thymus glucocorticoid receptor.

Formula: C₂₅H₃₄F₂O₆

Purity: 99.32%

Color and Shape: Solid

Molecular weight: 468.53

Ref: TM-T34383