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CAS 144481-98-1

:

Landiolol hydrochloride

Description:
Landiolol hydrochloride is a selective beta-1 adrenergic antagonist primarily used in clinical settings for its rapid onset and short duration of action, making it suitable for managing acute tachycardia and hypertension. It is a synthetic compound characterized by its ability to effectively lower heart rate and myocardial oxygen demand without significantly affecting peripheral vascular resistance. The substance is typically administered intravenously, allowing for precise control over dosing and immediate therapeutic effects. Its pharmacokinetic profile includes a rapid distribution phase and a short half-life, which necessitates continuous infusion for sustained effects. Landiolol hydrochloride is generally well-tolerated, with a side effect profile that may include hypotension and bradycardia. As with other beta-blockers, caution is advised in patients with pre-existing respiratory conditions or heart block. The compound's chemical structure features a unique arrangement that contributes to its selectivity and efficacy, making it a valuable tool in acute cardiovascular management.
Formula:C25H39N3O8·ClH
InChI:InChI=1S/C25H39N3O8.ClH/c1-25(2)35-18-22(36-25)17-34-23(30)8-5-19-3-6-21(7-4-19)33-16-20(29)15-26-9-10-27-24(31)28-11-13-32-14-12-28;/h3-4,6-7,20,22,26,29H,5,8-18H2,1-2H3,(H,27,31);1H/t20-,22+;/m0./s1
InChI key:InChIKey=DLPGJHSONYLBKP-IKGOIYPNSA-N
SMILES:C(CC(OC[C@H]1OC(C)(C)OC1)=O)C2=CC=C(OC[C@H](CNCCNC(=O)N3CCOCC3)O)C=C2.Cl
Synonyms:
  • Benzenepropanoic acid, 4-[(2S)-2-hydroxy-3-[[2-[(4-morpholinylcarbonyl)amino]ethyl]amino]propoxy]-, [(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl ester, hydrochloride (1:1)
  • Benzenepropanoic acid, 4-[(2S)-2-hydroxy-3-[[2-[(4-morpholinylcarbonyl)amino]ethyl]amino]propoxy]-, [(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl ester, monohydrochloride
  • Benzenepropanoic acid, 4-[2-hydroxy-3-[[2-[(4-morpholinylcarbonyl)amino]ethyl]amino]propoxy]-, (2,2-dimethyl-1,3-dioxolan-4-yl)methyl ester, monohydrochloride, [S-(R*,R*)]-
  • Corebeta
  • ONO 1101 hydrochloride
  • Onoact
  • Rapibloc
  • [(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl 3-(4-{[(2S)-2-hydroxy-3-({2-[(morpholin-4-ylcarbonyl)amino]ethyl}amino)propyl]oxy}phenyl)propanoate hydrochloride (1:1)
  • [(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl 3-[4-[(2S)-2-hydroxy-3-[2-(morpholine-4-carbonylamino)ethylamino]propoxy]phenyl]propanoate hydrochloride
  • Landiolol hydrochloride
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Found 8 products.