CAS 1445085-82-4

[2′-(Amino-κN)[1,1′-biphenyl]-2-yl-κC][dicyclohexyl(2′,6′-dimethoxy[1,1′-biphenyl]-2-yl)phosphine-κP](methanesulfonato-κO)palladium

Description:

The chemical substance with the name "[2′-(Amino-κN)[1,1′-biphenyl]-2-yl-κC][dicyclohexyl(2′,6′-dimethoxy[1,1′-biphenyl]-2-yl)phosphine-κP](methanesulfonato-κO)palladium" and CAS number "1445085-82-4" is a palladium complex that features a bidentate ligand system. This compound is characterized by the presence of a palladium center coordinated to a phosphine ligand and an amino-substituted biphenyl moiety. The methanesulfonate group serves as a counterion, enhancing the solubility and stability of the complex in various solvents. The biphenyl units contribute to the electronic properties of the complex, making it potentially useful in catalysis, particularly in cross-coupling reactions. The presence of the dimethoxy substituents may also influence the sterics and electronics of the ligand, affecting the reactivity and selectivity of the palladium center. Overall, this compound exemplifies the intricate design of metal complexes for applications in organic synthesis and catalysis.

Formula: C₃₉H₄₈NO₅PPdS

InChI: InChI=1S/C26H35O2P.C12H10N.CH4O3S.Pd/c1-27-23-17-11-18-24(28-2)26(23)22-16-9-10-19-25(22)29(20-12-5-3-6-13-20)21-14-7-4-8-15-21;13-12-9-5-4-8-11(12)10-6-2-1-3-7-10;1-5(2,3)4;/h9-11,16-21H,3-8,12-15H2,1-2H3;1-6,8-9H,13H2;1H3,(H,2,3,4);/q;-1;;+2/p-1

InChI key: InChIKey=AGPKJDBFYITZDC-UHFFFAOYSA-M

SMILES: [P]([Pd+2]1([O-]S(C)(=O)=O)[C-]=2C(C=3C([NH2]1)=CC=CC3)=CC=CC2)(C4=C(C=CC=C4)C5=C(OC)C=CC=C5OC)(C6CCCCC6)C7CCCCC7

Synonyms:

• Methanesulfonato(2-dicyclohexylphosphino-2',6'-dimethoxy-1,1'-biphenyl)(2'-amino-1,1'-biphenyl-2-yl)palladium(II)
• Palladium, [2′-(amino-κN)[1,1′-biphenyl]-2-yl-κC][dicyclohexyl(2′,6′-dimethoxy[1,1′-biphenyl]-2-yl)phosphine-κP](methanesulfonato-κO)-
• SPhos Palladacycle
• SPhos Pd G3
• [2′-(Amino-κN)[1,1′-biphenyl]-2-yl-κC][dicyclohexyl(2′,6′-dimethoxy[1,1′-biphenyl]-2-yl)phosphine-κP](methanesulfonato-κO)palladium

Methanesulfonato(2-dicyclohexylphosphino-2',6'-dimethoxy-1,1'-biphenyl)(2'-amino-1,1'-biphenyl-2-yl)palladium(II) dichloromethane adduct min. 98% [SPhos Palladacycle Gen. 3]

CAS: 1445085-82-4

Methanesulfonato(2-dicyclohexylphosphino-2',6'-dimethoxy-1,1'-biphenyl)(2'-amino-1,1'-biphenyl-2-yl)palladium(II) dichloromethane adduct min. 98% [SPhos Palladacycle Gen. 3]

Formula: C₃₉H₄₈NO₅PPdS

Purity: min. 98%

Color and Shape: beige to yellow solid

Molecular weight: 780.26

Ref: 08-46-0318

Palladium, [2'-(amino-κN)[1,1'-biphenyl]-2-yl-κC][dicyclohexyl(2',6'-dimethoxy[1,1'-biphenyl]-2-yl)phosphine-κP](methanesulfonato-κO)-

CAS: 1445085-82-4

Formula: C₃₉H₄₈NO₅PPdS

Purity: 95%

Color and Shape: Solid

Molecular weight: 780.2609

Ref: IN-DA001JNQ

(2-Dicyclohexylphosphino-2,6-DimethoxyBiphenyl)[2-(2-Amino-1,1-Biphenyl)]Palladium(II) Methanesulfonate

CAS: 1445085-82-4

(2-Dicyclohexylphosphino-2,6-DimethoxyBiphenyl)[2-(2-Amino-1,1-Biphenyl)]Palladium(II) Methanesulfonate

Purity: 98%

Molecular weight: 875.36g/mol

Ref: 54-IN10293

SPhos Pd G3

CAS: 1445085-82-4

Purity: 95%

Molecular weight: 780.27

Ref: 10-F983683

SPhosPdG3

CAS: 1445085-82-4

SPhosPdG3, a bifunctional ligand, is capable of binding to the kinetochore-microtubule interface and inhibiting mitosis in cells. SPhosPdG3 binds to the kinetochore-microtubule interface and inhibits mitosis by altering the spindle checkpoint. The ligand has been shown to bind to the bromodomain on proteins that are involved in cancer development and progression, such as CDK4/CDK6 and BRD2. SPhosPdG3 has been shown to have inhibitory potency for these protein kinases in vitro. This compound may be useful for treating cancer through targeting these pathways.

Formula: C₃₉H₄₈NO₅PPdS

Purity: Min. 95%

Molecular weight: 780.26 g/mol

Ref: 3D-VHC08582