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CAS 144510-96-3

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Pixantrone

Description:
Pixantrone is a synthetic anthracenedione derivative primarily used as an anticancer agent. It exhibits a unique mechanism of action, primarily functioning as a topoisomerase II inhibitor, which interferes with DNA replication and transcription, ultimately leading to cell death in rapidly dividing cancer cells. Pixantrone is characterized by its ability to form stable complexes with DNA, resulting in the induction of double-strand breaks. This compound is notable for its reduced cardiotoxicity compared to other anthracyclines, making it a valuable option in treating certain hematological malignancies, particularly in patients who have previously been treated with other therapies. Its solubility profile and pharmacokinetics are designed to optimize its therapeutic efficacy while minimizing adverse effects. Pixantrone is typically administered intravenously and has been evaluated in clinical trials for its effectiveness against various types of cancer, including non-Hodgkin lymphoma. As with any chemotherapeutic agent, careful monitoring for side effects and interactions with other medications is essential during treatment.
Formula:C17H19N5O2
InChI:InChI=1S/C17H19N5O2/c18-4-7-21-12-1-2-13(22-8-5-19)15-14(12)16(23)10-3-6-20-9-11(10)17(15)24/h1-3,6,9,21-22H,4-5,7-8,18-19H2
InChI key:InChIKey=PEZPMAYDXJQYRV-UHFFFAOYSA-N
SMILES:N(CCN)C1=C2C(=C(NCCN)C=C1)C(=O)C=3C(C2=O)=CC=NC3
Synonyms:
  • 6,9-Bis((2-Aminoethyl)Amino)Benzo(G)Isoquinoline-5,10-Dione
  • 6,9-Bis[(2-aminoethyl)amino]benz[g]isoquinoline-5,10-dione
  • Benz[g]isoquinoline-5,10-dione, 6,9-bis[(2-aminoethyl)amino]-
  • Pixantrone
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