CymitQuimica logo

CAS 1445379-61-2

:

2′-Deoxy-3′-O-[(1,1-dimethylethyl)dimethylsilyl]-2′-fluoro-4′-C-(hydroxymethyl)uridine

Description:
2′-Deoxy-3′-O-[(1,1-dimethylethyl)dimethylsilyl]-2′-fluoro-4′-C-(hydroxymethyl)uridine is a modified nucleoside that exhibits unique structural characteristics due to the presence of a fluorine atom and a silyl protecting group. This compound features a uridine backbone, which is a nucleoside composed of a ribose sugar and a uracil base, with specific modifications that enhance its stability and bioactivity. The 2′-fluoro substitution contributes to increased resistance to enzymatic degradation, making it potentially useful in therapeutic applications, particularly in antiviral and anticancer research. The presence of the tert-butyldimethylsilyl group provides protection for the hydroxyl group at the 3′ position, facilitating further chemical modifications or incorporation into oligonucleotides. Additionally, the hydroxymethyl group at the 4′ position may influence the compound's interaction with biological targets. Overall, this compound represents a valuable tool in nucleic acid chemistry and molecular biology, with implications for drug design and development.
Formula:C16H27FN2O6Si
InChI:InChI=1S/C16H27FN2O6Si/c1-15(2,3)26(4,5)25-12-11(17)13(24-16(12,8-20)9-21)19-7-6-10(22)18-14(19)23/h6-7,11-13,20-21H,8-9H2,1-5H3,(H,18,22,23)/t11-,12+,13-/m1/s1
InChI key:InChIKey=FQCJMRIFHYTBRI-FRRDWIJNSA-N
SMILES:O([Si](C(C)(C)C)(C)C)[C@@H]1C(CO)(CO)O[C@H]([C@@H]1F)N2C(=O)NC(=O)C=C2
Synonyms:
  • Uridine, 2′-deoxy-3′-O-[(1,1-dimethylethyl)dimethylsilyl]-2′-fluoro-4′-C-(hydroxymethyl)-
  • 2′-Deoxy-3′-O-[(1,1-dimethylethyl)dimethylsilyl]-2′-fluoro-4′-C-(hydroxymethyl)uridine
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
Found 3 products.