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CAS 1445379-92-9

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4′-C-(Chloromethyl)-2′-deoxy-2′-fluorocytidine

Description:
4′-C-(Chloromethyl)-2′-deoxy-2′-fluorocytidine is a synthetic nucleoside analog that features modifications to the cytidine structure, specifically at the 2' and 4' positions. The presence of a chloromethyl group at the 4' position and a fluorine atom at the 2' position enhances its potential as an antiviral or anticancer agent by altering its interaction with nucleic acid synthesis pathways. This compound is characterized by its ability to mimic natural nucleosides, which allows it to be incorporated into nucleic acids, potentially disrupting normal cellular processes. Its chemical structure contributes to its stability and bioactivity, making it a subject of interest in medicinal chemistry. The compound's unique properties may lead to specific therapeutic applications, particularly in targeting viral replication or cancer cell proliferation. As with many nucleoside analogs, its efficacy and safety profile would be evaluated through rigorous pharmacological studies.
Formula:C10H13ClFN3O4
InChI:InChI=1S/C10H13ClFN3O4/c11-3-10(4-16)7(17)6(12)8(19-10)15-2-1-5(13)14-9(15)18/h1-2,6-8,16-17H,3-4H2,(H2,13,14,18)/t6-,7+,8-,10-/m1/s1
InChI key:InChIKey=AWSRKKBIPSQHOJ-IBCQBUCCSA-N
SMILES:C(Cl)[C@]1(CO)O[C@H]([C@H](F)[C@@H]1O)N2C(=O)N=C(N)C=C2
Synonyms:
  • Cytidine, 4′-C-(chloromethyl)-2′-deoxy-2′-fluoro-
  • ALS 8112
  • 4′-C-(Chloromethyl)-2′-deoxy-2′-fluorocytidine
  • 4-amino-1-((2R,3R,4R,5R)-5-(chloromethyl)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one
  • ALS-8176 (active form)
  • 4-Amino-1-[5-chloro-2,5-dideoxy-2-fluoro-4-(hydroxymethyl)-a-L-lyxofuranosyl]-2(1H)-pyrimidinone
  • 4'-chloromethyl-2'-deoxy-2'-fluorocytidine
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