CAS 1445379-92-9

4′-C-(Chloromethyl)-2′-deoxy-2′-fluorocytidine

Description:

4′-C-(Chloromethyl)-2′-deoxy-2′-fluorocytidine is a synthetic nucleoside analog that features modifications to the cytidine structure, specifically at the 2' and 4' positions. The presence of a chloromethyl group at the 4' position and a fluorine atom at the 2' position enhances its potential as an antiviral or anticancer agent by altering its interaction with nucleic acid synthesis pathways. This compound is characterized by its ability to mimic natural nucleosides, which allows it to be incorporated into nucleic acids, potentially disrupting normal cellular processes. Its chemical structure contributes to its stability and bioactivity, making it a subject of interest in medicinal chemistry. The compound's unique properties may lead to specific therapeutic applications, particularly in targeting viral replication or cancer cell proliferation. As with many nucleoside analogs, its efficacy and safety profile would be evaluated through rigorous pharmacological studies.

Formula: C₁₀H₁₃ClFN₃O₄

InChI: InChI=1S/C10H13ClFN3O4/c11-3-10(4-16)7(17)6(12)8(19-10)15-2-1-5(13)14-9(15)18/h1-2,6-8,16-17H,3-4H2,(H2,13,14,18)/t6-,7+,8-,10-/m1/s1

InChI key: InChIKey=AWSRKKBIPSQHOJ-IBCQBUCCSA-N

SMILES: C(Cl)[C@]1(CO)O[C@H]([C@H](F)[C@@H]1O)N2C(=O)N=C(N)C=C2

Synonyms:

• Cytidine, 4′-C-(chloromethyl)-2′-deoxy-2′-fluoro-
• ALS 8112
• 4′-C-(Chloromethyl)-2′-deoxy-2′-fluorocytidine
• 4-amino-1-((2R,3R,4R,5R)-5-(chloromethyl)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one
• ALS-8176 (active form)
• 4-Amino-1-[5-chloro-2,5-dideoxy-2-fluoro-4-(hydroxymethyl)-a-L-lyxofuranosyl]-2(1H)-pyrimidinone
• 4'-chloromethyl-2'-deoxy-2'-fluorocytidine

ALS-8112

CAS: 1445379-92-9

ALS-8112

Purity: ≥98%

Molecular weight: 293.68g/mol

Ref: 54-BUP21615

ALS-8112

CAS: 1445379-92-9

Please enquire for more information about ALS-8112 including the price, delivery time and more detailed product information at the technical inquiry form on this page

Formula: C₁₀H₁₃ClFN₃O₄

Purity: Min. 95%

Molecular weight: 293.68 g/mol

Ref: 3D-VHC37992

ALS-8112

CAS: 1445379-92-9

ALS-8112 is a inhibitor of respiratory syncytial virus (RSV) polymerase. The 5'-triphosphate form of ALS-8112 inhibits RSV polymerase (IC50: 0.02 μM).

Formula: C₁₀H₁₃ClFN₃O₄

Purity: 98.90%

Color and Shape: Solid

Molecular weight: 293.68

Ref: TM-T14195