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(10E)-10,11-Didehydro-11-deoxy-6-O-methylerythromycin

CAS 144604-03-5: (10E)-10,11-Didehydro-11-deoxy-6-O-methylerythromycin

Description:(10E)-10,11-Didehydro-11-deoxy-6-O-methylerythromycin is a semi-synthetic derivative of erythromycin, which is a macrolide antibiotic. This compound is characterized by its unique structural modifications that enhance its pharmacological properties. The presence of the didehydro group at the 10 and 11 positions contributes to its increased potency against certain bacterial strains, while the 11-deoxy modification helps in reducing susceptibility to bacterial resistance mechanisms. The 6-O-methyl group further alters its solubility and bioavailability. This compound exhibits antibacterial activity primarily against Gram-positive bacteria and some Gram-negative bacteria, making it useful in treating various infections. Its mechanism of action involves inhibiting bacterial protein synthesis by binding to the 50S ribosomal subunit. Additionally, (10E)-10,11-Didehydro-11-deoxy-6-O-methylerythromycin may have a favorable pharmacokinetic profile, allowing for effective oral administration. However, like other antibiotics, it is essential to use it judiciously to minimize the risk of developing antibiotic resistance.

Formula:C38H67NO12

InChI:InChI=1S/C38H67NO12/c1-15-27-36(8,44)17-20(2)29(40)21(3)18-38(10,46-14)33(51-35-30(41)26(39(11)12)16-22(4)47-35)23(5)31(24(6)34(43)49-27)50-28-19-37(9,45-13)32(42)25(7)48-28/h17,21-28,30-33,35,41-42,44H,15-16,18-19H2,1-14H3/b20-17+/t21-,22-,23+,24-,25+,26+,27-,28+,30-,31+,32+,33-,35+,36+,37-,38-/m1/s1

InChI key:InChIKey=XBRPMQCVVSGOJB-LUHVZOSXSA-N

SMILES:O=C1OC(CC)C(O)(C=C(C(=O)C(C)CC(OC)(C)C(OC2OC(C)CC(N(C)C)C2O)C(C)C(OC3OC(C)C(O)C(OC)(C)C3)C1C)C)C

  • Synonyms:
  • Erythromycin, 10,11-didehydro-11-deoxy-6-O-methyl-, (10E)-
  • Oxacyclotetradecane, erythromycin deriv.
  • (10E)-10,11-Didehydro-11-deoxy-6-O-methylerythromycin
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Found 4 products.

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Anhydroclarithromycin

CAS:144604-03-5

Ref: 45-1A03650

25mg1,145.00 €
Estimated delivery in United States, on Tuesday 11 Mar 2025
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Ref: 4Z-C-3714

5mgTo inquire
10mgTo inquire
25mgTo inquire
50mgTo inquire
100mgTo inquire
Estimated delivery in United States, on Tuesday 11 Mar 2025
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(10E)-10,11-Didehydro-11-deoxy-6-O-methylerythromycin

Controlled Product
CAS:144604-03-5

Ref: TR-D297530

10mg187.00 €
25mg368.00 €
50mg670.00 €
Estimated delivery in United States, on Thursday 20 Mar 2025
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(10E)-10,11-Didehydro-11-deoxy-6-O-methylerythromycin

CAS:144604-03-5

Ref: 3D-AD21727

1mg147.00 €
2mg184.00 €
5mg276.00 €
10mg432.00 €
25mg732.00 €
Estimated delivery in United States, on Monday 21 Apr 2025
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