CAS 1446321-46-5

2-Hydroxy-6-[[2-[1-(1-methylethyl)-1H-pyrazol-5-yl]-3-pyridinyl]methoxy]benzaldehyde

Description:

2-Hydroxy-6-[[2-[1-(1-methylethyl)-1H-pyrazol-5-yl]-3-pyridinyl]methoxy]benzaldehyde is a complex organic compound characterized by its unique structural features, which include a hydroxyl group, a benzaldehyde moiety, and a pyrazole-pyridine linkage. This compound is likely to exhibit properties typical of phenolic compounds, such as potential antioxidant activity, due to the presence of the hydroxyl group. The presence of the pyrazole and pyridine rings suggests that it may also exhibit biological activity, possibly interacting with various biological targets. Its molecular structure indicates that it could be soluble in organic solvents, and its reactivity may be influenced by the functional groups present. The compound's specific applications could range from pharmaceuticals to agrochemicals, depending on its biological activity and stability. As with many organic compounds, its behavior in different environments, such as pH and temperature, would be essential for understanding its practical uses and safety profile.

Formula: C₁₉H₁₉N₃O₃

InChI: InChI=1S/C19H19N3O3/c1-13(2)22-16(8-10-21-22)19-14(5-4-9-20-19)12-25-18-7-3-6-17(24)15(18)11-23/h3-11,13,24H,12H2,1-2H3

InChI key: InChIKey=FWCVZAQENIZVMY-UHFFFAOYSA-N

SMILES: C(OC1=C(C=O)C(O)=CC=C1)C2=C(N=CC=C2)C=3N(C(C)C)N=CC3

Synonyms:

• GBT 440
• 2-Hydroxy-6-[[2-[1-(1-methylethyl)-1H-pyrazol-5-yl]-3-pyridinyl]methoxy]benzaldehyde
• Benzaldehyde, 2-hydroxy-6-[[2-[1-(1-methylethyl)-1H-pyrazol-5-yl]-3-pyridinyl]methoxy]-
• 2-hydroxy-6-{[2-[1-(propan-2-yl)-1H-pyrazol-5-yl]pyridin-3-yl]methoxy}benzaldehyde
• Voxelotor

Hemoglobin Modulators-1

CAS: 1446321-46-5

Formula: C₁₉H₁₉N₃O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 337.3725

Ref: IN-DA00ABO0

voxelotor

CAS: 1446321-46-5

voxelotor

Purity: ≥98%

Molecular weight: 337.37g/mol

Ref: 54-BUP13023

Voxelotor

CAS: 1446321-46-5

Formula: C₁₉H₁₉N₃O₃

Molecular weight: 337.38

Ref: 4Z-V-099001

voxelotor

CAS: 1446321-46-5

Voxelotor (GBT 440) is an orally novel hemoglobin S (HbS) polymerization inhibitor used for the treatment of sickle cell disease (SCD). Cost-effective and quality-assured.

Formula: C₁₉H₁₉N₃O₃

Purity: 99.9% - 99.94%

Color and Shape: Solid

Molecular weight: 337.37

Ref: TM-T7581

2-HYDROXY-6-((2-(1-ISOPROPYL-1H-PYRAZOL-5-YL)PYRIDIN-3-YL)METHOXY)BENZALDEHYDE

CAS: 1446321-46-5

Purity: 95.0%

Molecular weight: 337.3789978027344

Ref: 10-F539209

GBT 440

CAS: 1446321-46-5

Applications GBT 440 is a potent allosteric effector of sickle cell hemoglobin (Hb) that increases the affinity of Hb for oxygen and inhibits its polymerization when subjected to hypoxic conditions.
References Metcalf, B., et al.: ACS Med. Chem., 8, 321-326 (2017); Li, Q., et al.: Proc. Natl. Acad. Sci. U.S.A., 114, E689-E696 (2017)

Formula: C₁₉H₁₉N₃O₃

Color and Shape: Neat

Molecular weight: 337.37

Ref: TR-G268015

Voxelotor

Controlled Product

CAS: 1446321-46-5

Voxelotor is an oral therapeutic agent, which is a small molecule obtained through synthetic chemistry with targeted activity on hemoglobin. Its mode of action involves the allosteric modification of hemoglobin, specifically increasing hemoglobin oxygen affinity. By stabilizing the oxygenated hemoglobin state, voxelotor reduces the sickling and polymerization of red blood cells that are characteristic of sickle cell disease (SCD).

Formula: C₁₉H₁₉N₃O₃

Purity: Min. 98 Area-%

Color and Shape: White Powder

Molecular weight: 337.37 g/mol

Ref: 3D-FH167609