CAS 1446322-66-2

TAT-cyclo-CLLFVY

Description:

TAT-cyclo-CLLFVY, identified by its CAS number 1446322-66-2, is a synthetic peptide that has garnered attention in the field of biochemistry and molecular biology. This compound is characterized by its cyclic structure, which enhances its stability and bioactivity compared to linear peptides. The TAT portion refers to a transactivator of transcription (TAT) peptide derived from the HIV-1 virus, known for its ability to facilitate cellular uptake of various molecules, including peptides and proteins. The sequence CLLFVY is indicative of specific amino acids that contribute to the peptide's functional properties, such as cell-penetrating capabilities and potential therapeutic applications. TAT-cyclo-CLLFVY is often studied for its role in drug delivery systems, particularly in targeting cells for therapeutic interventions. Its unique structure and properties make it a valuable tool in research, particularly in studies involving gene therapy, cancer treatment, and other biomedical applications. As with any synthetic peptide, its stability, solubility, and interaction with biological systems are critical factors influencing its effectiveness in various applications.

Formula: C₁₁₁H₁₈₈N₄₂O₂₄S₂

Synonyms:

• TAT-cyclo-CLLFVY

TAT-cyclo-CLLFVY

CAS: 1446322-66-2

Blocks HIF-1α/β dimerization, not HIF-2α; suppresses VEGF, CAIX in cancer cells; antiangiogenic in HUVECs (IC50 = 1.3 μM).

Formula: C₁₁₁H₁₈₈N₄₂O₂₄S₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 2559.1

Ref: TM-TP2046

Tat-cyclo-cllfvy

CAS: 1446322-66-2

Tat-cyclo-cllfvy is a cell-penetrating peptide, which is a synthetic compound designed for therapeutic applications. It is derived from natural peptide sequences, engineered to facilitate efficient cellular uptake without significant toxicity or disruption of cellular membranes. The mode of action involves the facilitated transport of the peptide across the lipid bilayer of cells, leveraging its amphipathic structure to interact with cellular membranes and enable intracellular delivery of attached therapeutic agents.

Formula: C₁₁₁H₁₈₈N₄₂O₂₄S₂

Purity: Min. 95%

Molecular weight: 2,559.1 g/mol

Ref: 3D-WHC32266