CAS 14464-29-0

Acetic acid N-hydroxysuccinimide ester

Description:

Acetic acid N-hydroxysuccinimide ester, commonly referred to as NHS-acetate, is a chemical compound that serves as a reactive intermediate in various biochemical applications, particularly in the field of bioconjugation. It is characterized by its ability to form stable amide bonds with primary amines, making it useful for labeling proteins, peptides, and other biomolecules. The compound features a succinimide ring, which enhances its reactivity towards nucleophiles, and an acetic acid moiety that contributes to its solubility in polar solvents. NHS-acetate is typically used in the synthesis of NHS esters, which are favored for their mild reaction conditions and ability to selectively modify biomolecules without significant side reactions. This compound is generally stable under dry conditions but can hydrolyze in the presence of moisture, leading to the release of acetic acid and the corresponding NHS. Its applications extend to drug development, diagnostics, and the preparation of bioconjugates for therapeutic purposes. Proper handling and storage are essential to maintain its reactivity and effectiveness in laboratory settings.

Formula: C₆H₇NO₄

InChI: InChI=1S/C6H7NO4/c1-4(8)11-7-5(9)2-3-6(7)10/h2-3H2,1H3

InChI key: InChIKey=SIFCHNIAAPMMKG-UHFFFAOYSA-N

SMILES: O(C(C)=O)N1C(=O)CCC1=O

Synonyms:

• (2,5-Dioxopyrrolidin-1-yl) acetate
• 1-(Acetoxy)pyrrolidine-2,5-dione
• 1-(Acetyloxy)-2,5-pyrrolidinedione
• 1-(Acetyloxy)Pyrrolidine-2,5-Dione
• 2,5-Pyrrolidinedione, 1-(acetyloxy)-
• Ac-Osu
• Acetic Acid-N-Succinimido Ester
• N-Acetoxysuccinimide
• N-Hydroxysuccinimide acetate
• N-Hydroxysuccinimidyl acetate
• O-Acetyl-N,N-succinyl hydroxylamine
• Succinimide, N-acetoxy-
• Succinimidyl Acetate

N-Succinimidyl Acetate

CAS: 14464-29-0

Formula: C₆H₇NO₄

Purity: >98.0%(GC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 157.13

Ref: 3B-S0878

2,5-Pyrrolidinedione, 1-(acetyloxy)-

CAS: 14464-29-0

Formula: C₆H₇NO₄

Purity: 97%

Color and Shape: Solid

Molecular weight: 157.1241

Ref: IN-DA001JWF

Acetic acid N-hydroxysuccinimide ester

CAS: 14464-29-0

Acetic acid N-hydroxysuccinimide ester

Formula: C₆H₇NO₄

Purity: 99%

Color and Shape: white crystalline powder

Molecular weight: 157.12g/mol

Ref: 54-BIA1015

Acetic acid N-hydroxysuccinimide ester

CAS: 14464-29-0

Acetic acid N-hydroxysuccinimide ester is a reactive compound that reacts with lysine residues in proteins. It is used as an analytical reagent and chemical intermediate. Acetic acid N-hydroxysuccinimide ester reacts with carbonyl groups to form Schiff bases, which are then reacted with amino groups on the protein molecule to form acyl-amino adducts. This reaction can be followed by analysis using high performance liquid chromatography (HPLC) or mass spectroscopy.

Formula: C₆H₇NO₄

Purity: Min. 97.5 Area-%

Color and Shape: White Powder

Molecular weight: 157.12 g/mol

Ref: 3D-FA33719

2,5-Dioxopyrrolidin-1-yl acetate

CAS: 14464-29-0

Formula: C₆H₇NO₄

Purity: 95%

Color and Shape: Solid

Molecular weight: 157.125

Ref: 10-F229127

N-Acetoxysuccinimide

Controlled Product

CAS: 14464-29-0

Stability Moisture Sensitive
Applications N-Acetoxysuccinimide (cas# 14464-29-0) is a useful research chemical.

Formula: C₆H₇NO₄

Color and Shape: Neat

Molecular weight: 157.12

Ref: TR-A164295