CAS 1446700-26-0

2-Propenamide, N-[3-[[2-[[4-(4-acetyl-1-piperazinyl)-2-methoxyphenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]phenyl]-, hydrobromide (1:1)

Description:

2-Propenamide, N-[3-[[2-[[4-(4-acetyl-1-piperazinyl)-2-methoxyphenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]phenyl]-, hydrobromide (1:1) is a complex organic compound characterized by its multi-functional structure, which includes a propenamide moiety and various aromatic and heterocyclic components. The presence of a trifluoromethyl group enhances its lipophilicity and may influence its biological activity. The hydrobromide salt form indicates that it is likely soluble in water, which can facilitate its use in pharmaceutical applications. This compound may exhibit specific interactions with biological targets due to its diverse functional groups, making it a candidate for research in medicinal chemistry. Its synthesis and characterization would typically involve standard organic reactions, and its stability, solubility, and reactivity would be of interest in both laboratory and therapeutic contexts. As with many such compounds, safety and handling precautions are essential due to potential toxicity or reactivity associated with its components.

Formula: C₂₇H₂₉BrF₃N₇O₃

InChI: InChI=1S/C27H28F3N7O3.BrH/c1-4-24(39)32-18-6-5-7-19(14-18)33-25-21(27(28,29)30)16-31-26(35-25)34-22-9-8-20(15-23(22)40-3)37-12-10-36(11-13-37)17(2)38;/h4-9,14-16H,1,10-13H2,2-3H3,(H,32,39)(H2,31,33,34,35);1H

InChI key: InChIKey=IPKRDUJIGYXXNT-UHFFFAOYSA-N

SMILES: N(C=1C(C(F)(F)F)=CN=C(NC2=C(OC)C=C(C=C2)N3CCN(C(C)=O)CC3)N1)C4=CC(NC(C=C)=O)=CC=C4.Br

Synonyms:

• 2-Propenamide, N-[3-[[2-[[4-(4-acetyl-1-piperazinyl)-2-methoxyphenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]phenyl]-, hydrobromide (1:1)
• AVL-301 HBr salt, CNX-419 HBr salt
• CNX-419 hydrobroMide
• ROCILETINIB HYDROBROMIDE; AVL-301 HYDROBROMIDE; CNX-419 HYDROBROMIDE
• CNX-419 HBr
• AVL-301 hydrobroMide
• CO-1686 (hydrobroMide)
• Rociletinib (CO-1686,AVL-301) HBr
• Rociletinib hydrobromide (CO1686
• Rociletinib hydrobromide
• CO-1686 HBr salt,Rociletinib HBr salt

2-Propenamide, N-[3-[[2-[[4-(4-acetyl-1-piperazinyl)-2-methoxyphenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]phenyl]-, hydrobromide (1:1)

CAS: 1446700-26-0

Formula: C₂₇H₂₉BrF₃N₇O₃

Purity: 98.04%

Molecular weight: 636.4635

Ref: IN-DA001JYR

Rociletinib hydrobromide

CAS: 1446700-26-0

Rociletinib hydrobromide is an orally delivered inhibitor of the mutant form of EGFR kinase (Kis: 21.5 nM and 303.3 nM for EGFR L858R/T790M and EGFR WT).

Formula: C₂₇H₂₉BrF₃N₇O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 636.46

Ref: TM-T14993