CAS 144689-24-7: Olmesartan
Description:Olmesartan is an angiotensin II receptor antagonist primarily used in the treatment of hypertension. It belongs to the class of medications known as sartans, which work by blocking the action of angiotensin II, a hormone that causes blood vessels to constrict. This action leads to vasodilation, resulting in lowered blood pressure. Chemically, olmesartan is characterized by its complex structure, which includes a biphenyl group and a carboxylate moiety, contributing to its pharmacological activity. The substance is typically administered in the form of olmesartan medoxomil, a prodrug that is converted into its active form in the body. Olmesartan is known for its long half-life, allowing for once-daily dosing. It is generally well-tolerated, though potential side effects may include dizziness, headache, and gastrointestinal disturbances. As with other antihypertensive agents, it is important to monitor renal function and potassium levels during treatment. Overall, olmesartan is an effective option for managing high blood pressure and reducing the risk of cardiovascular events.
Formula:C24H26N6O3
InChI:InChI=1S/C24H26N6O3/c1-4-7-19-25-21(24(2,3)33)20(23(31)32)30(19)14-15-10-12-16(13-11-15)17-8-5-6-9-18(17)22-26-28-29-27-22/h5-6,8-13,33H,4,7,14H2,1-3H3,(H,31,32)(H,26,27,28,29)
InChI key:InChIKey=VTRAEEWXHOVJFV-UHFFFAOYSA-N
SMILES:O=C(O)C1=C(N=C(N1CC=2C=CC(=CC2)C=3C=CC=CC3C4=NN=NN4)CCC)C(O)(C)C
- Synonyms:
- 1H-Imidazole-5-carboxylic acid, 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-
- 1H-Imidazole-5-carboxylic acid, 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-
- 1H-Imidazole-5-carboxylicacid, 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-
- 4-(1-Hydroxy-1-methylethyl)-2-propyl-1-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid
- Cs 088
- Olmesartan
- Olmetor
- Rnh 6270