CAS 144689-24-7

Olmesartan

Description:

Olmesartan is an angiotensin II receptor antagonist primarily used in the treatment of hypertension. It belongs to the class of medications known as sartans, which work by blocking the action of angiotensin II, a hormone that causes blood vessels to constrict. This action leads to vasodilation, resulting in lowered blood pressure. Chemically, olmesartan is characterized by its complex structure, which includes a biphenyl group and a carboxylate moiety, contributing to its pharmacological activity. The substance is typically administered in the form of olmesartan medoxomil, a prodrug that is converted into its active form in the body. Olmesartan is known for its long half-life, allowing for once-daily dosing. It is generally well-tolerated, though potential side effects may include dizziness, headache, and gastrointestinal disturbances. As with other antihypertensive agents, it is important to monitor renal function and potassium levels during treatment. Overall, olmesartan is an effective option for managing high blood pressure and reducing the risk of cardiovascular events.

Formula: C₂₄H₂₆N₆O₃

InChI: InChI=1S/C24H26N6O3/c1-4-7-19-25-21(24(2,3)33)20(23(31)32)30(19)14-15-10-12-16(13-11-15)17-8-5-6-9-18(17)22-26-28-29-27-22/h5-6,8-13,33H,4,7,14H2,1-3H3,(H,31,32)(H,26,27,28,29)

InChI key: InChIKey=VTRAEEWXHOVJFV-UHFFFAOYSA-N

SMILES: C(N1C(C(O)=O)=C(C(C)(C)O)N=C1CCC)C2=CC=C(C=C2)C3=C(C=CC=C3)C=4NN=NN4

Synonyms:

• 1H-Imidazole-5-carboxylic acid, 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-
• 1H-Imidazole-5-carboxylic acid, 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-
• 1H-Imidazole-5-carboxylicacid, 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-
• 4-(1-Hydroxy-1-methylethyl)-2-propyl-1-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid
• Cs 088
• Olmesartan
• Olmetor
• Rnh 6270

Olmesartan

CAS: 144689-24-7

Formula: C₂₄H₂₆N₆O₃

Purity: >98.0%(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 446.51

Ref: 3B-O0507

Olmesartan

CAS: 144689-24-7

Color and Shape: Neat

Ref: 61-FOR1317.01

1H-Imidazole-5-carboxylic acid, 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-

CAS: 144689-24-7

Formula: C₂₄H₂₆N₆O₃

Purity: 98%

Color and Shape: Solid

Molecular weight: 446.5016

Ref: IN-DA001K0E

1-((2'-(1H-Tetrazol-5-Yl)-[1,1'-Biphenyl]-4-Yl)Methyl)-4-(2-Hydroxypropan-2-Yl)-2-Propyl-1H-Imidazole-5-Carboxylic Acid

CAS: 144689-24-7

1-((2'-(1H-Tetrazol-5-Yl)-[1,1'-Biphenyl]-4-Yl)Methyl)-4-(2-Hydroxypropan-2-Yl)-2-Propyl-1H-Imidazole-5-Carboxylic Acid

Purity: 98%

Molecular weight: 446.5g/mol

Ref: 54-OR1026226

Olmesartan (Olmesartan Medoxomil EP Impurity A)

CAS: 144689-24-7

Formula: C₂₄H₂₆N₆O₃

Color and Shape: White To Off-White Solid

Molecular weight: 446.51

Ref: 4Z-O-081

Olmesartan

CAS: 144689-24-7

Olmesartan

Purity: ≥90%

Molecular weight: 446.5g/mol

Ref: 54-BUP13846

Olmesartan

CAS: 144689-24-7

Formula: C₂₉H₃₀N₆O₆

Purity: (HPLC) ≥ 98.0%

Color and Shape: White to off-white powder

Molecular weight: 558.59

Ref: 7W-GP5497

Olmesartan-d64 Acid(dimethyl-d6)

CAS: 1185144-74-4, 144689-24-7

Purity: 99 atom % D

Molecular weight: 452.54

Ref: 3U-D7522

Olmesartan 100 µg/mL in Acetonitrile:Methanol

Controlled Product

CAS: 144689-24-7

Formula: C₂₄H₂₆N₆O₃

Color and Shape: Single Solution

Molecular weight: 446.50

Ref: 04-A15727200MC-100

Olmesartan

CAS: 144689-24-7

Purity: 98%

Molecular weight: 446.510986328125

Ref: 10-F787557

Olmesartan

CAS: 144689-24-7

Formula: C₂₄H₂₆N₆O₃

Color and Shape: Neat

Molecular weight: 446.50

Ref: 04-C15727200

4-(1-Hydroxy-1-methylethyl)-2-propyl-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-imidazole-5-carboxylic Acid (Olmesartan)

Controlled Product

CAS: 144689-24-7

Formula: C₂₄H₂₆N₆O₃

Color and Shape: Neat

Molecular weight: 446.50

Ref: 86-MM1317.01

Olmesartan

CAS: 144689-24-7

Olmesartan (RNH 6270) is an Angiotensin II Type I receptor antagonist.

Formula: C₂₄H₂₆N₆O₃

Purity: 91.89% - 99.81%

Color and Shape: White To Beige Solid Solid

Molecular weight: 446.50

Ref: TM-T5964

Olmesartan Medoxomil EP Impurity A

CAS: 144689-24-7

Formula: C₂₄H₂₆N₆O₃

Molecular weight: 446.51

Ref: ST-EA-CP-O7001

Olmesartan Acid

Controlled Product

CAS: 144689-24-7

Impurity Olmesartan EP Impurity A
Applications Olmesartan Acid (Olmesartan EP Impurity A) is an angiotensin II receptor antagonist. Used as an anti-hypertensive.
References Yanagisawa, H., et al.: J. Med. Chem., 39, 323 (1996), Puchler, K., et al.: J. Hypertens., 15, 1809 (1997),

Formula: C₂₄H₂₆N₆O₃

Color and Shape: White To Beige

Molecular weight: 446.5

Ref: TR-O550001

Olmesartan

CAS: 144689-24-7

Olmesartan medoxomil is a prodrug that is hydrolyzed to olmesartan, its active form. It is a member of the angiotensin II receptor antagonists and it is used for the treatment of hypertension and heart failure. Olmesartan medoxomil reduces the risk of cardiovascular events in patients with resistant hypertension or heart failure. The drug binds to the angiotensin II type 1 receptor, thereby blocking the binding of angiotensin II to this receptor. This prevents activation of downstream signaling pathways, including phospholipase C, protein kinase C, and mitogen-activated protein kinases. Olmesartan medoxomil also blocks the formation of new blood vessels and vascular remodeling in animal models.

Formula: C₂₄H₂₆N₆O₃

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 446.5 g/mol

Ref: 3D-IH57928