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CAS 144689-78-1

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Olmesartan

Description:
Olmesartan is an angiotensin II receptor antagonist primarily used in the treatment of hypertension. It belongs to the class of medications known as sartans, which work by blocking the action of angiotensin II, a hormone that causes blood vessels to constrict. This action leads to vasodilation, resulting in lowered blood pressure. The chemical formula of olmesartan is C19H18N4O6, and it has a molecular weight of approximately 362.37 g/mol. It is typically administered in the form of olmesartan medoxomil, a prodrug that is converted into its active form in the body. Olmesartan is characterized by its high oral bioavailability and long half-life, allowing for once-daily dosing. It is generally well-tolerated, with common side effects including dizziness, headache, and gastrointestinal disturbances. Additionally, olmesartan has been associated with renal protective effects, making it beneficial for patients with conditions such as diabetes. As with all medications, it is important for patients to consult healthcare professionals for personalized advice and monitoring.
Formula:C30H32N6O6
InChI:InChI=1S/C30H32N6O6/c1-5-6-11-24-31-26(30(3,4)39)25(28(37)40-17-23-18(2)41-29(38)42-23)36(24)16-19-12-14-20(15-13-19)21-9-7-8-10-22(21)27-32-34-35-33-27/h7-10,12-15,39H,5-6,11,16-17H2,1-4H3,(H,32,33,34,35)
SMILES:CCCCc1nc(c(C(=O)OCc2c(C)oc(=O)o2)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)C(C)(C)O
Synonyms:
  • (5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 2-butyl-4-(2-hydroxy-2-propanyl)-1-{[2'-(2H-tetrazol-5-yl)-4-biphenylyl]methyl}-1H-imidazole-5-carboxylate
  • 4-(1-Hydroxy-1-methylethyl)-2-propyl-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid
  • (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-{[2'-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazole-5-carboxylate
  • 4-(2-hydroxypropan-2-yl)-2-propyl-1-{[2'-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazole-5-carboxylic acid
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