CAS 144690-92-6

Tritylolmesartan medoxomil

Description:

Tritylolmesartan medoxomil is a pharmaceutical compound primarily used as an antihypertensive agent. It is a prodrug of olmesartan, which means it is converted into its active form in the body. The compound features a complex molecular structure that includes a trityl group, enhancing its lipophilicity and bioavailability. Tritylolmesartan medoxomil acts as an angiotensin II receptor blocker (ARB), specifically targeting the AT1 receptor, which plays a crucial role in regulating blood pressure and fluid balance. By inhibiting this receptor, the compound effectively reduces vasoconstriction and promotes vasodilation, leading to lower blood pressure. Its pharmacokinetic properties include good absorption and a relatively long half-life, allowing for once-daily dosing. Additionally, it is characterized by its stability under physiological conditions and its ability to provide sustained antihypertensive effects. As with many medications, potential side effects may include dizziness, headache, or gastrointestinal disturbances, but it is generally well-tolerated in patients.

Formula: C₄₈H₄₄N₆O₆

InChI: InChI=1S/C48H44N6O6/c1-5-17-41-49-43(47(3,4)57)42(45(55)58-31-40-32(2)59-46(56)60-40)53(41)30-33-26-28-34(29-27-33)38-24-15-16-25-39(38)44-50-51-52-54(44)48(35-18-9-6-10-19-35,36-20-11-7-12-21-36)37-22-13-8-14-23-37/h6-16,18-29,57H,5,17,30-31H2,1-4H3

InChI key: InChIKey=IJOPLMOXIPGJIJ-UHFFFAOYSA-N

SMILES: C(N1C(=NN=N1)C2=C(C=CC=C2)C3=CC=C(CN4C(C(OCC5=C(C)OC(=O)O5)=O)=C(C(C)(C)O)N=C4CCC)C=C3)(C6=CC=CC=C6)(C7=CC=CC=C7)C8=CC=CC=C8

Synonyms:

• (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-{[2'-(1-trityl-1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazole-5-carboxylate
• 1,3-Dioxole, 1H-imidazole-5-carboxylic acid deriv.
• 1H-Imidazole-5-carboxylic acid,4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-,(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester
• 5-Methoxy-2-oxo-1,3-dioxol-4-yl) methyl-4-(1-hydroxy-1-methylethyl-2 propyl-1-(2-(2-triphenylmethyl)-2H-tetrazole-5-yl) biphenyl-4-yl) methyl)-1H-imidazole-5-carboxylate
• Omst-C
• Trityl Olmesartan Medoximil (N-1)
• Trityl Olmesartan Medoxomil
• Trityl olmesartan
• Tritylolmesartan medoxomil

4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2'-[1-(triphenylmethyl)-1h-tetrazol-5-yl][1,1'-biphenyl]-4-yl]methyl]-1h-imidazole-5-carboxylic acid (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester

CAS: 144690-92-6

Formula: C₄₈H₄₄N₆O₆

Purity: 98%

Color and Shape: Solid

Molecular weight: 800.8996

Ref: IN-DA001K06

Tritylolmesartan Medoxomil

CAS: 144690-92-6

Tritylolmesartan medoxomil is a precursor to olmesartan medoxomil, an AT1 antagonist prodrug.

Formula: C₄₈H₄₄N₆O₆

Color and Shape: White To Light Yellow Solid Powder

Molecular weight: 800.9

Ref: TM-T35642

Trityl olmesartan Medoxomil

CAS: 144690-92-6

Formula: C₄₈H₄₄N₆O₆

Molecular weight: 800.92

Ref: ST-EA-CP-O7025

4-(1-Hydroxy-1-methylethyl)-2-propyl-1[4-[2-(trityltetrazol-5-yl)phenyl]phenyl]methylimidazo-5-carboxylate (5-methyl-2-oxo-1,3-dioxo len-4-yl)methyl

CAS: 144690-92-6

5-methyl-2-oxo-1,3-dioxo-4-[(4-[2-(trityl)phenyl]phenyl)methylimidazo]-5-carboxylate is a drug that belongs to the group of angiotensin II receptor antagonists. The main human metabolite is the product of N-dealkylation at the nitrogen atom of the imidazole ring. It has been shown to inhibit rat liver microsomes at concentrations of 2.5 and 5 μM. This compound is also found as an impurity in cilexetil and olmesartan, which are other drugs belonging to this class. Impurities can be detected by using metal hydroxides, amines and biphenyl as reagents, or with gas chromatography/mass spectrometry (GC/MS), liquid chromatography/mass spectrometry (LC/MS), or high performance liquid chromatography/mass

Formula: C₄₈H₄₄N₆O₆

Purity: Min. 95%

Color and Shape: Solid

Molecular weight: 800.9 g/mol

Ref: 3D-IH57932

N1-Trityl Olmesartan Medoxomil

CAS: 144690-92-6

Formula: C₄₈H₄₄N₆O₆

Color and Shape: White To Off-White Solid

Molecular weight: 800.92

Ref: 4Z-O-0810