CAS 14470-28-1

4-Methoxytrityl chloride

Description:

4-Methoxytrityl chloride, with the CAS number 14470-28-1, is an organic compound commonly used in organic synthesis, particularly in the field of nucleic acid chemistry. It is characterized by the presence of a methoxy group (-OCH3) attached to a trityl group, which is a bulky, stable protecting group for hydroxyl functionalities. This compound typically appears as a white to off-white solid and is soluble in organic solvents such as dichloromethane and chloroform. Its reactivity is primarily attributed to the presence of the chloride functional group, which can participate in nucleophilic substitution reactions. 4-Methoxytrityl chloride is often employed to protect hydroxyl groups in the synthesis of oligonucleotides, allowing for selective reactions without interference from other functional groups. Safety precautions should be taken when handling this compound, as it may be irritant and requires proper storage conditions to maintain its stability.

Formula: C₂₀H₁₇ClO

InChI: InChI=1S/C20H17ClO/c1-22-19-14-12-18(13-15-19)20(21,16-8-4-2-5-9-16)17-10-6-3-7-11-17/h2-15H,1H3

InChI key: InChIKey=OBOHMJWDFPBPKD-UHFFFAOYSA-N

SMILES: C(Cl)(C1=CC=C(OC)C=C1)(C2=CC=CC=C2)C3=CC=CC=C3

Synonyms:

• (p-Anisyl)diphenylmethyl chloride
• 1-(Chlorodiphenylmethyl)-4-Methoxybenzene
• 4-Anisyl(chloro)diphenylmethane
• 4-Methoxytriphenylchloromethane
• 4-Methoxytrityl chloride
• 4-Monomethoxytrityl chloride
• Anisole, p-(chlorodiphenylmethyl)-
• Benzene, 1-(chlorodiphenylmethyl)-4-methoxy-
• MMTCl
• Mmt-Cl
• Mono-p-methoxytrityl chloride
• NSC 54121
• [(Chloro)(4-methoxyphenyl)methylene]dibenzene
• p-(Chlorodiphenylmethyl)anisole
• p-Anisylchlorodiphenylmethane

4-Methoxytrityl Chloride [Hydroxyl Protecting Agent]

CAS: 14470-28-1

Formula: C₂₀H₁₇ClO

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Light yellow to Light orange powder to crystal

Molecular weight: 308.81

Ref: 3B-M0790

4-Methoxytrityl chloride, 97%

CAS: 14470-28-1

It is used as selective protecting reagent that is used for primary hydroxyl groups. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item

Formula: C₂₀H₁₇ClO

Purity: 97%

Color and Shape: Crystals or powder or crystalline powder, White to cream to pale orange or pink

Molecular weight: 308.81

Ref: 02-A10545

Benzene, 1-(chlorodiphenylmethyl)-4-methoxy-

CAS: 14470-28-1

Formula: C₂₀H₁₇ClO

Purity: 95%

Color and Shape: Solid

Molecular weight: 308.8014

Ref: IN-DA001K10

1-[Chloro(diphenyl)methyl]-4-methoxybenzene

CAS: 14470-28-1

Purity: 97.0%

Color and Shape: Solid

Molecular weight: 308.80999755859375

Ref: 10-F067663

4-Methoxytrityl chloride

CAS: 14470-28-1

4-Methoxytrityl chloride

Formula: C₂₀H₁₇ClO

Purity: 98%

Color and Shape: orange crystals

Molecular weight: 308.80g/mol

Ref: 54-OR906880

4-Anisylchlorodiphenylmethane

CAS: 14470-28-1

4-Anisylchlorodiphenylmethane is a trifluoroacetic acid derivative of diphenyl sulfoxide. It is activated by hydrochloric acid and hydrogen chloride to form the corresponding anisyl chlorodiphenylmethane chloride. This compound has a high resistance to nucleophilic attack, with a reaction solution that is resistant to nucleophiles such as water, amines, alcohols, and carboxylic acids. 4-Anisylchlorodiphenylmethane can be synthesized from uridine and acetic acid in the presence of diphenyl sulfoxide and a base. The reaction is then heated at reflux for 24 hours. 4-Anisylchlorodiphenylmethane binds to DNA as well as RNA templates in vitro and can be used for linear regression analysis of DNA sequences. It also has inhibitory effects on cell growth in culture.

Formula: C₂₀H₁₇ClO

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 308.8 g/mol

Ref: 3D-FA10230

4-Methoxytriphenylmethylchloride

Controlled Product

CAS: 14470-28-1

Applications 4-Methoxyriphenylmethylchloride is used in the synthesis of N-sulfonyl imines.
References Khalafi-Nezhad, A. et al.: Can. J. Chem., 86, 456 (2008);

Formula: C₂₀H₁₇ClO

Color and Shape: Neat

Molecular weight: 308.8

Ref: TR-M271660