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CAS 144702-17-0

:

Pomisartan

Description:
Pomisartan, with the CAS number 144702-17-0, is an angiotensin II receptor antagonist primarily used in the treatment of hypertension. It functions by selectively blocking the action of angiotensin II, a potent vasoconstrictor, thereby promoting vasodilation and reducing blood pressure. The chemical structure of Pomisartan includes a biphenyl group and a carboxylic acid moiety, contributing to its pharmacological activity. It is typically administered orally and exhibits a relatively long half-life, allowing for once-daily dosing. Pomisartan is known for its favorable side effect profile compared to other antihypertensives, with a lower incidence of cough and angioedema, which are common with ACE inhibitors. Additionally, it may provide renal protective effects, making it beneficial for patients with diabetic nephropathy. As with any medication, monitoring for potential interactions and contraindications is essential, particularly in patients with renal impairment or those taking other antihypertensive agents. Overall, Pomisartan represents an effective option in the management of high blood pressure.
Formula:C31H30N4O2
InChI:InChI=1/C31H30N4O2/c1-3-28-33-30-20(2)16-23(26-19-34-15-7-6-10-29(34)32-26)17-27(30)35(28)18-21-11-13-22(14-12-21)24-8-4-5-9-25(24)31(36)37/h4-5,8-9,11-14,16-17,19H,3,6-7,10,15,18H2,1-2H3,(H,36,37)
SMILES:CCc1nc2c(C)cc(cc2n1Cc1ccc(cc1)c1ccccc1C(=O)O)c1cn2CCCCc2n1
Synonyms:
  • Pomisartan [INN]
  • 4'-((2-Ethyl-4-methyl-6-(5,6,7,8-tetrahydroimidazo(1,2-a)pyridin-2-yl)-1-benzimidazolyl)methyl)-2-biphenylcarboxylic acid
  • Unii-7539319Jyi
  • 4'-{[2-ethyl-4-methyl-6-(5,6,7,8-tetrahydroimidazo[1,2-a]pyridin-2-yl)-1H-benzimidazol-1-yl]methyl}biphenyl-2-carboxylic acid
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