CAS 144750-42-5

Clopidogrel USP Related Compound A

Description:

Clopidogrel USP Related Compound A, with the CAS number 144750-42-5, is a chemical substance that is structurally related to the antiplatelet medication clopidogrel. It is primarily characterized by its role as an impurity or degradation product in the synthesis of clopidogrel. This compound is typically identified through analytical techniques such as high-performance liquid chromatography (HPLC) and mass spectrometry. Its molecular structure features specific functional groups that contribute to its chemical behavior and stability. Clopidogrel itself is a prodrug that requires metabolic activation to exert its pharmacological effects, and related compounds like Compound A may exhibit varying degrees of biological activity or toxicity. The presence of such related compounds is important for quality control in pharmaceutical formulations, as they can influence the efficacy and safety of the final product. Regulatory guidelines often dictate the acceptable limits for these impurities to ensure patient safety and drug effectiveness.

Formula: C₁₅H₁₄ClNO₂S·ClH

InChI: InChI=1S/C15H14ClNO2S.ClH/c16-12-4-2-1-3-11(12)14(15(18)19)17-7-5-13-10(9-17)6-8-20-13;/h1-4,6,8,14H,5,7,9H2,(H,18,19);1H/t14-;/m0./s1

InChI key: InChIKey=FOKSIOUPGDBSLC-UQKRIMTDSA-N

SMILES: [C@H](C(O)=O)(N1CC2=C(CC1)SC=C2)C3=C(Cl)C=CC=C3.Cl

Synonyms:

• (+)-(S)-(o-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-acetic acid, hydrochloride
• (2S)-(2-Chlorophenyl)(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetic acid hydrochloride (1:1)
• (S)-2-(2-Chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetic acid hydrochloride
• (αS)-α-(2-Chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-acetic acid hydrochloride (1:1)
• Clopidogrel Related Compound A
• Thieno[3,2-c]pyridine-5(4H)-acetic acid, α-(2-chlorophenyl)-6,7-dihydro-, hydrochloride (1:1), (αS)-
• Thieno[3,2-c]pyridine-5(4H)-acetic acid, α-(2-chlorophenyl)-6,7-dihydro-, hydrochloride, (αS)-
• Clopidogrel Related Compound A (20 mg) ((S)-(ochlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-aceticv acid, hydrochloride)
• Clopidogrel Impurity 1 HCl(Clopidogrel EP Impurity A HCl)
• CLOPIDOGREL RELATED COMPOUND A (20 MG) ((S)-(O-CHLOROPHENYL)-6,7-DIHYDROTHIENO[3,2-C]PYRI-DINE-5(4H)-ACETIC ACID, HYDROCHLORIDE)
• Clopidogrel carboxylic acid Impurity
• Clopidogrel USP Related CoMpound A
• Clopidogrel Related Compound A as Hydrochloride
• Clopidogrel Impurity 2/Clopidogrel EP Impurity A HCl/(S)-Clopidogrel Acid Hydrochloride/(S)-2-(2-Chlorophenyl)-2-(6,7-dihydrothieno-[3,2-c]pyridin-5(4H)-yl)acetic acid hydrochloride
• Clopidogrel USP Related Compound A as Hydrochloride
• alpha-(2-Chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-acetic acid hydrochloride
• Clopidogrel Hydrogen Sulfate EP Impurity A as Hydrochloride
• (+)-(S)-(o-Chlorophenyl)-6,7-dihydrothieno3,2-cpyridine-5(4H)-acetic acid hydrochloride
• Clopidogrel USP RC A
• Clopidogrel Hydrogen Sulfate Impurity A as Hydrochloride
• (S)-(2-Chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-acetic acid hydrochloride
• (S)-2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetic acid hydrochloride? (Clopidogrel Impurity）
• Clopidogrel acid hydrochloride
• Clopidogrel EP Impurity A HCl
• Clopidogrel EP IMpurity-A
• Clopidogrel Related Compound A ((+)-(S)-(o-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-ace (1140586)
• Clopidogrel Carboxylic Acid Hydrochloride Salt
• Clopidogrel Impurity A（EP）
• Clopidogrel Related Compound A (H0M124)
• Clopidogrel EP impurity-A (USP RC A)
• Clopidogrel Carboxylic Acid Hydrochloride

CLOPIDOGREL IMPURITY A CRS

CAS: 144750-42-5

CLOPIDOGREL IMPURITY A CRS

Ref: 41-Y0001335

Clopidogrel Related Compound A ((+)-(S)-(o-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-acetic acid, hydrochloride)

CAS: 144750-42-5

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Formula: C₁₅H₁₄ClNO₂S·HCl

Color and Shape: Off-White Powder

Molecular weight: 307.04338

Ref: 45-1140586

Thieno[3,2-c]pyridine-5(4H)-acetic acid, α-(2-chlorophenyl)-6,7-dihydro-, hydrochloride (1:1), (αS)-

CAS: 144750-42-5

Formula: C₁₅H₁₅Cl₂NO₂S

Purity: 95%

Color and Shape: Solid

Molecular weight: 344.2561

Ref: IN-DA001K3J

(S)-2-(2-Chlorophenyl)-2-(6,7-Dihydrothieno[3,2-c]Pyridin-5(4H)-Yl)Acetic Acid Hydrochloride

CAS: 144750-42-5

(S)-2-(2-Chlorophenyl)-2-(6,7-Dihydrothieno[3,2-c]Pyridin-5(4H)-Yl)Acetic Acid Hydrochloride

Purity: 98%

Molecular weight: 344.26g/mol

Ref: 54-OR1028086

(2S)-(2-Chlorophenyl)[6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl]acetic Acid Hydrochloride (Clopidogrel Acid Hydrochloride)

CAS: 144750-42-5

Color and Shape: Neat

Ref: 86-MM0455.04

(S)-2-(2-Chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetic acid hydrochloride

CAS: 144750-42-5

Purity: 95.0%

Molecular weight: 344.25

Ref: 10-F237891

Clopidogrel Carboxylic Acid hydrochloride

CAS: 144750-42-5

Clopidogrel Carboxylic Acid hydrochloride (SR 26334) is a major inactive metabolite of clopidogrel, commonly used as a reference standard for metabolic analysi.

Formula: C₁₅H₁₅Cl₂NO₂S

Purity: 99.32%

Color and Shape: Solid

Molecular weight: 344.26

Ref: TM-T36112

Clopidogrel Carboxylic Acid Hydrochloride

Controlled Product

CAS: 144750-42-5

Impurity Clopidogrel EP Impurity A; Clopidogrel Impurity A; Clopidogrel USP A
Stability Hygroscopic
Applications Clopidogrel Carboxylic Acid Hydrochloride (Clopidogrel EP Impurity A; Clopidogrel Impurity A; Clopidogrel USP A) is the hydrochloride salt of a metabolite of the drug Clopidogrel.
References Savi, P., et al.: Biochem. Pharmacol., 44, 527 (1992), Pereillo, J., et al.: Drug Metab. Dispos., 30, 1288 (2002), Ksycinska, H., et al.: J. Pharm. Biomed. Anal., 41, 533 (2006), Farid, N., et al.: Clin. Pharmacol. Ther., 81, 735 (2007),

Formula: C₁₅H₁₄ClNO₂S·ClH

Color and Shape: Light Yellow

Molecular weight: 344.26

Ref: TR-C587235

(R)- Clopidogrel Carboxylic Acid Hydrochloride

Controlled Product

CAS: 144750-42-5

Formula: C₁₅H₁₄ClNO₂S·HCl

Color and Shape: Neat

Molecular weight: 344.26

Ref: TR-C587231

Clopidogrel Impurity A

CAS: 144750-42-5

Clopidogrel Impurity A is a medicine that is used for the prevention of heart attacks, strokes, and blood clots in people with an increased risk of these events. It is not intended to be used for immediate relief from sudden symptoms. Clopidogrel Impurity A is a substance that may be found in some preparations of clopidogrel. The presence of this substance can be detected by liquid chromatography-mass spectrometry (LC-MS/MS) methods. The structural analysis of this substance was determined using enantiomeric resolution and chromatographic methods. This impurity has been shown to have no effect on the bioavailability of the parent drug, clopidogrel, when given orally to Sprague-Dawley rats.

Formula: C₁₅H₁₅Cl₂NO₂S

Purity: Min. 95%

Molecular weight: 344.26 g/mol

Ref: 3D-IC158706