CAS 144822-63-9

1-[5-O-[Bis(4-methoxyphenyl)phenylmethyl]-2-deoxy-2-fluoro-beta-D-arabinofuranosyl]-2,4(1H,3H)-pyrimidinedione

Description:

1-[5-O-[Bis(4-methoxyphenyl)phenylmethyl]-2-deoxy-2-fluoro-beta-D-arabinofuranosyl]-2,4(1H,3H)-pyrimidinedione, with CAS number 144822-63-9, is a synthetic nucleoside analog characterized by its complex structure, which includes a pyrimidinedione core and a modified sugar moiety. This compound features a 2-deoxy-2-fluoro-beta-D-arabinofuranosyl group, which enhances its stability and bioactivity compared to natural nucleosides. The presence of the bis(4-methoxyphenyl)phenylmethyl substituent contributes to its lipophilicity, potentially influencing its pharmacokinetic properties. The compound is of interest in medicinal chemistry, particularly for its potential antiviral or anticancer activities, as modifications to nucleosides can affect their interaction with nucleic acid targets. Its unique structural features may also impact its solubility, reactivity, and binding affinity to enzymes or receptors involved in nucleic acid metabolism. Further studies are necessary to elucidate its biological activity and therapeutic potential.

Formula: C₃₀H₂₉FN₂O₇

InChI: InChI=1/C30H29FN2O7/c1-37-22-12-8-20(9-13-22)30(19-6-4-3-5-7-19,21-10-14-23(38-2)15-11-21)39-18-24-27(35)26(31)28(40-24)33-17-16-25(34)32-29(33)36/h3-17,24,26-28,35H,18H2,1-2H3,(H,32,34,36)/t24-,26+,27-,28?/m1/s1

Synonyms:

• 1-{5-O-[Bis-(4-methoxyphenyl)-phenylmethyl]-2-deoxy-2-fluoro--D-arabinofuranosyl}-2,4(1H,3H)-pyrimidinedione
• 1-[(3S,4R,5R)-5-[[bis(4-methoxyphenyl)-phenyl-methoxy]methyl]-3-fluoro-4-hydroxy-tetrahydrofuran-2-yl]pyrimidine-2,4-dione

5'-O-DMT-2'-deoxy-2'-fluoro-β-D-arabinouridine

CAS: 144822-63-9

5'-O-DMT-2'-deoxy-2'-fluoro-β-D-arabinouridine is a Nucleoside Derivative - Fluoro-modified nucleoside, Protected nucleoside with NH2/OH open.

Formula: C₃₀H₂₉FN₂O₇

Color and Shape: Solid

Molecular weight: 548.56

Ref: TM-TNU1172

1-(2'-Deoxy-5'-O-DMT-2'-fluoro-b-D-arabinofuranosyl)uracil

CAS: 144822-63-9

1-(2'-Deoxy-5'-O-DMT-2'-fluoro-b-D-arabinofuranosyl)uracil is a nucleoside analog and contains a uracil base, and a 2'-deoxy-5'-O-DMT-2'-fluoro-b-D-arabinofuranosyl sugar moiety. The 2'-fluoro modification is of particular interest due to its potential to alter the chemical and biological properties of the resulting oligonucleotides. Fluorinated nucleosides and their analogs have been extensively studied for their antiviral and anticancer activities. The incorporation of fluorine into nucleoside analogs can also affect their interaction with DNA and RNA, leading to changes in their therapeutic potential.

Formula: C₃₀H₂₉FN₂O₇

Purity: Min. 95%

Color and Shape: White To Off-White Solid

Molecular weight: 548.56 g/mol

Ref: 3D-ND09139