CAS 1448428-04-3
:Selonsertib
Description:
Selonsertib, with the CAS number 1448428-04-3, is a small molecule inhibitor primarily targeting the protein kinase known as apoptosis signal-regulating kinase 1 (ASK1). This compound has garnered attention for its potential therapeutic applications, particularly in the treatment of liver diseases, including nonalcoholic steatohepatitis (NASH) and other fibrotic conditions. Selonsertib functions by modulating cellular stress responses and inflammation, which are critical in the progression of liver fibrosis. The substance is characterized by its specific chemical structure, which includes a unique arrangement of functional groups that contribute to its biological activity. In preclinical and clinical studies, selonsertib has demonstrated the ability to reduce liver inflammation and fibrosis, making it a candidate for further investigation in hepatology. However, as with many investigational drugs, its efficacy and safety profile continue to be evaluated through ongoing research and clinical trials.
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Found 9 products.
5-(4-Cyclopropyl-1H-Imidazol-1-Yl)-2-Fluoro-N-(6-(4-Isopropyl-4H-1,2,4-Triazol-3-Yl)Pyridin-2-Yl)-4-Methylbenzamide
CAS:<p>5-(4-Cyclopropyl-1H-Imidazol-1-Yl)-2-Fluoro-N-(6-(4-Isopropyl-4H-1,2,4-Triazol-3-Yl)Pyridin-2-Yl)-4-Methylbenzamide</p>Purity:97%Molecular weight:445.49g/molSelonsertib
CAS:<p>Selonsertib (GS-4997), an oral ASK1 inhibitor, may have anti-inflammatory, anti-fibrotic, and anti-cancer effects.</p>Formula:C24H24FN7OPurity:95.04% - 99.53%Color and Shape:SolidMolecular weight:445.49Selonsertib
CAS:Controlled Product<p>Applications Selonsertib is an apoptosis signal-regulating kinase 1 (ASK1) inhibitor with potential anti-inflammatory, antineoplastic and anti-fibrotic activities. Selonsertib interacts with the catalytic kinase domain of ASK1 and prevents its phosphorylation and activation. As a result, the expression of genes involved in fibrosis, cellular proliferation, and apoptosis are down regulated.<br>References Nelson, C. H. et al.: Clin Pharmacol Ther. 98, 630 (2015); Lin, J. H., et al.: Nephron. 129, 29 (2015)<br></p>Formula:C24H24FN7OColor and Shape:NeatMolecular weight:445.49Selonsertib
CAS:<p>Selonsertib is a highly selective inhibitor of the ATP-binding cassette transporter (ABCA1) that belongs to the class of glp-1 analogues. It is used in combination with other drugs for the treatment of bowel disease, autoimmune diseases, and skin cancer. Selonsertib has been shown to be active against a number of cell types and is also effective in models of metabolic disorders such as hepatic steatosis and kidney fibrosis. Selonsertib blocks ABCA1 by binding to its ATP-binding site, inhibiting cholesterol efflux from cells. This drug may work by restoring mitochondrial membrane potential, which may help prevent or reverse cellular damage caused by oxidative stress.</p>Formula:C24H24FN7OPurity:Min. 95%Molecular weight:445.49 g/mol
