CAS 144849-63-8

Bisnafide

Description:

Bisnafide, with the CAS number 144849-63-8, is a chemical compound that belongs to the class of bisphosphonates, which are primarily used in the treatment of bone-related disorders. This substance is characterized by its ability to inhibit osteoclast-mediated bone resorption, making it valuable in managing conditions such as osteoporosis and Paget's disease. Bisnafide exhibits a unique molecular structure that allows it to bind to hydroxyapatite in bone, enhancing its therapeutic efficacy. It is typically administered in a specific dosage form, and its pharmacokinetics involve absorption, distribution, metabolism, and excretion processes that are crucial for its effectiveness. Safety and efficacy profiles are established through clinical studies, and like other bisphosphonates, it may have side effects that need to be monitored. Overall, Bisnafide represents an important advancement in the pharmacological management of bone health, contributing to improved patient outcomes in various skeletal disorders.

Formula: C₃₂H₂₈N₆O₈

InChI: InChI=1/C32H28N6O8/c1-17(35-29(39)23-7-3-5-19-11-21(37(43)44)13-25(27(19)23)31(35)41)15-33-9-10-34-16-18(2)36-30(40)24-8-4-6-20-12-22(38(45)46)14-26(28(20)24)32(36)42/h3-8,11-14,17-18,33-34H,9-10,15-16H2,1-2H3/t17-,18-/m1/s1

Synonyms:

• UNII-62H4W26906
• Bisnafide [INN]
• 2,2'-{ethane-1,2-diylbis[imino(2R)propane-1,2-diyl]}bis(5-nitro-1H-benzo[de]isoquinoline-1,3(2H)-dione)

Bisnafide

CAS: 144849-63-8

Bisnafide: a DNA intercalating, topo II inhibiting Naphthalimide that normalizes tumor vessels, enhancing cytotoxic delivery.

Formula: C₃₂H₂₈N₆O₈

Purity: 98%

Color and Shape: Solid

Molecular weight: 624.6

Ref: TM-T25159