CAS 1449-05-4

18α-Glycyrrhetinic acid

Description:

18α-Glycyrrhetinic acid is a triterpenoid compound derived from glycyrrhizin, which is found in the root of the licorice plant (Glycyrrhiza glabra). It is characterized by its pentacyclic structure, which includes a cyclopentanoperhydrophenanthrene core. This compound exhibits a range of biological activities, including anti-inflammatory, antiviral, and hepatoprotective properties, making it of interest in pharmacological research. It is often studied for its potential therapeutic effects in conditions such as liver diseases and viral infections. 18α-Glycyrrhetinic acid is also known to inhibit the enzyme 11β-hydroxysteroid dehydrogenase type 2, which can affect cortisol metabolism and has implications for conditions related to steroid hormone regulation. In terms of solubility, it is generally more soluble in organic solvents than in water, which can influence its bioavailability and application in formulations. Overall, its diverse biological activities and natural origin contribute to its significance in both traditional medicine and modern pharmacology.

Formula: C₃₀H₄₆O₄

InChI: InChI=1S/C30H46O4/c1-25(2)21-8-11-30(7)23(28(21,5)10-9-22(25)32)20(31)16-18-19-17-27(4,24(33)34)13-12-26(19,3)14-15-29(18,30)6/h16,19,21-23,32H,8-15,17H2,1-7H3,(H,33,34)/t19-,21+,22+,23-,26-,27+,28+,29-,30-/m1/s1

InChI key: InChIKey=MPDGHEJMBKOTSU-PMTKVOBESA-N

SMILES: C[C@]12[C@@]([C@]3(C)[C@@](CC1)(C(C)(C)[C@@H](O)CC3)[H])(C(=O)C=C4[C@@]2(C)CC[C@]5(C)[C@@]4(C[C@](C(O)=O)(C)CC5)[H])[H]

Synonyms:

• (3Beta)-3-Hydroxy-11-Oxoolean-12-En-30-Oate
• (3Beta)-3-Hydroxy-11-Oxoolean-12-En-30-Oic Acid
• (3Beta,18Alpha)-3-Hydroxy-11-Oxoolean-12-En-30-Oic Acid
• (3beta,18alpha,20beta)-3-Hydroxy-11-oxoolean-12-en-29-oic acid
• (3β,18α,20β)-3-Hydroxy-11-oxoolean-12-en-29-oic acid
• 18-Isoglycyrrhetinic acid
• 18-alpha-Olean-12-en-30-oic acid, 3-beta-hydroxy-11-oxo-
• 18-β Glycyrrhetinic Acid
• 18α-Glycyrrhetic acid
• 18α-Glycyrrhetinic acid
• 18α-Olean-12-en-30-oic acid, 3β-hydroxy-11-oxo-
• 3-Hydroxy-11-Oxoolean-12-En-29-Oic Acid
• 3-beta-Hydroxy-11-oxo-18-alpha-olean-12-en-30-oic acid
• Brn 2956366
• Ccris 3963
• Nsc 35350
• Olean-12-en-29-oic acid, 3-hydroxy-11-oxo-, (3β,18α,20β)-
• Stx 353
• beta-Glycyrrhetinic acid

18-α-Glycyrrhetinic acid

CAS: 1449-05-4

18-alpha-Glycyrrhetinic acid analytical standard provided with w/w absolute assay, to be used for quantitative titration.

Formula: C₃₀H₄₆O₄

Purity: (HPLC) ≥99%

Color and Shape: Powder

Molecular weight: 470.7

Ref: 11-2313S

ENOXOLONE IMPURITY A CRS

CAS: 1449-05-4

ENOXOLONE IMPURITY A CRS

Ref: 41-Y0002341

18α-Glycyrrhetic acid

CAS: 1449-05-4

Formula: C₃₀H₄₆O₄

Molecular weight: 470.69

Ref: 7W-GY7735

18α-Glycyrrhetinic acid

CAS: 1449-05-4

18α-Glycyrrhetinic acid

Purity: ≥98%

Molecular weight: 470.68g/mol

Ref: 54-BUP14230

18α-Glycyrrhetic acid

CAS: 1449-05-4

Formula: C₃₀H₄₆O₄

Purity: 95%~99%

Molecular weight: 470.694

Ref: BP-BP2125

18α-Glycyrrhetinic Acid

CAS: 1449-05-4

Formula: C₃₀H₄₆O₄

Molecular weight: 470.69

Ref: 4Z-B-227014

18α-Glycyrrhetinic acid

CAS: 1449-05-4

18α-Glycyrrhetinic acid (Enoxolone) is a pentacyclic triterpenoid derivative of the beta-amyrin type obtained from the hydrolysis of glycyrrhizic acid.

Formula: C₃₀H₄₆O₄

Purity: 98.54% - 99.68%

Color and Shape: Solid

Molecular weight: 470.68

Ref: TM-T2745

18α-glycyrrhetinic acid

CAS: 1449-05-4

Carboxylic acid with additional oxygen functions

Formula: C₃₀H₄₆O₄

Purity: ≥ 98.0 % (HPLC)

Color and Shape: Powder

Molecular weight: 470.7

Ref: 5G-82552

18-α-Glycyrrhetinic acid

Controlled Product

CAS: 1449-05-4

18-alpha-Glycyrrhetinic acid is an anti-inflammatory compound, which is a triterpenoid derivative sourced from the root of the licorice plant, Glycyrrhiza glabra. It exhibits its mode of action by inhibiting the activity of the enzyme 11-beta-hydroxysteroid dehydrogenase type 2 (11β-HSD2), which converts active glucocorticoids to their inactive forms. This inhibition leads to increased local concentrations of glucocorticoids, thereby enhancing their anti-inflammatory effects at the application site.

Formula: C₃₀H₄₆O₄

Purity: Min. 95 Area-%

Color and Shape: Powder

Molecular weight: 470.68 g/mol

Ref: 3D-FG67268

18α-Glycyrrhetinic Acid

Controlled Product

CAS: 1449-05-4

Applications 18α-Glycyrrhetinic Acid rapidly and reversibly blocks gap junction intercellular communication (GJIC).
References Guo, Y., et. al.: Am. J. Phys.: 276, L1018 (1999)

Formula: C₃₀H₄₆O₄

Color and Shape: Neat

Molecular weight: 470.68

Ref: TR-G735005

Enoxolone EP Impurity A

CAS: 1449-05-4

Formula: C₃₀H₄₆O₄

Molecular weight: 470.69

Ref: ST-EA-CP-E91001

Olean-12-en-29-oic acid, 3-hydroxy-11-oxo-, (3β,18α,20β)-

CAS: 1449-05-4

Formula: C₃₀H₄₆O₄

Color and Shape: Solid

Molecular weight: 470.6838

Ref: IN-DA001KBM