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CAS 144924-99-2

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N6-Benzoyl-2'-fluoro-2'-deoxyarabinoadenosine

Description:
N6-Benzoyl-2'-fluoro-2'-deoxyarabinoadenosine, with the CAS number 144924-99-2, is a modified nucleoside analog of adenosine. This compound features a benzoyl group at the N6 position and a fluorine atom at the 2' position of the ribose sugar, which is in the deoxyribose form. The presence of the benzoyl group enhances its lipophilicity, potentially improving its cellular uptake and bioavailability. The fluorine substitution at the 2' position can influence the compound's stability and interaction with nucleic acid targets, making it of interest in antiviral and anticancer research. This compound may exhibit altered biological activity compared to its unmodified counterparts, potentially affecting its role in nucleic acid metabolism and signaling pathways. Its unique structural features make it a valuable tool in medicinal chemistry and pharmacology, particularly in the development of therapeutics targeting viral infections or cancer. As with many nucleoside analogs, its efficacy and safety profile would require thorough investigation through preclinical and clinical studies.
Formula:C17H16FN5O4
Synonyms:
  • Benzamide, N-[9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-yl]-
  • N6-Benzoyl-2'-fluoro-2'-deoxyarabinoadenosine
  • 2'-F-N6-Bz-2'-ara-dA
  • N-(9-((2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide
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