CAS 145-63-1

Suramin

Description:

Suramin is a synthetic organic compound primarily known for its use as an antiparasitic agent, particularly in the treatment of African sleeping sickness caused by Trypanosoma brucei. It is classified as a polysulfonated naphthylurea and exhibits a complex structure featuring multiple sulfonate groups, which contribute to its solubility in water. Suramin functions by inhibiting various enzymes and disrupting cellular processes in parasites, thereby preventing their proliferation. The compound is administered intravenously due to its poor oral bioavailability. In addition to its antiparasitic properties, suramin has been investigated for potential applications in other medical conditions, including certain cancers and viral infections, although its use in these areas is less established. Suramin's pharmacokinetics involve a relatively long half-life, allowing for less frequent dosing. However, it can cause side effects, including allergic reactions and nephrotoxicity, necessitating careful monitoring during treatment. Overall, suramin remains an important compound in tropical medicine and pharmacology.

Formula: C₅₁H₄₀N₆O₂₃S₆

InChI: InChI=1S/C51H40N6O23S6/c1-25-9-11-29(49(60)54-37-13-15-41(83(69,70)71)35-21-33(81(63,64)65)23-43(45(35)37)85(75,76)77)19-39(25)56-47(58)27-5-3-7-31(17-27)52-51(62)53-32-8-4-6-28(18-32)48(59)57-40-20-30(12-10-26(40)2)50(61)55-38-14-16-42(84(72,73)74)36-22-34(82(66,67)68)24-44(46(36)38)86(78,79)80/h3-24H,1-2H3,(H,54,60)(H,55,61)(H,56,58)(H,57,59)(H2,52,53,62)(H,63,64,65)(H,66,67,68)(H,69,70,71)(H,72,73,74)(H,75,76,77)(H,78,79,80)

InChI key: InChIKey=FIAFUQMPZJWCLV-UHFFFAOYSA-N

SMILES: N(C(=O)C1=CC(NC(=O)C2=CC(NC(NC3=CC(C(NC4=CC(C(NC=5C6=C(C(S(=O)(=O)O)=CC5)C=C(S(=O)(=O)O)C=C6S(=O)(=O)O)=O)=CC=C4C)=O)=CC=C3)=O)=CC=C2)=C(C)C=C1)C=7C8=C(C(S(=O)(=O)O)=CC7)C=C(S(=O)(=O)O)C=C8S(=O)(=O)O

Synonyms:

• Farma 939
• 1,3,5-Naphthalenetrisulfonic acid, 8,8′-[ureylenebis[m-phenylenecarbonylimino(4-methyl-m-phenylene)carbonylimino]]di-
• Farma
• 8,8′-[Carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bis[1,3,5-naphthalenetrisulfonic acid]
• 1,3,5-Naphthalenetrisulfonic acid, 8,8′-[carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bis-

1,3,5-Naphthalenetrisulfonic acid, 8,8'-[carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bis-

CAS: 145-63-1

Formula: C₅₁H₄₀N₆O₂₃S₆

Purity: 98%

Color and Shape: Solid

Molecular weight: 1297.2797

Ref: IN-DA001KFK

Suramin

CAS: 145-63-1

Suramin

Purity: ≥98%

Ref: 54-BUP22429

Suramin

CAS: 145-63-1

Suramin is an RdRp and PTPase inhibitor with anti-parasitic, anti-tumor, and anti-angiogenic activities, inhibiting sirtuins and DNA topoisomerase II.

Formula: C₅₁H₄₀N₆O₂₃S₆

Purity: 99.80%

Color and Shape: Solid

Molecular weight: 1297.28

Ref: TM-T75303

Suramin

CAS: 145-63-1

Suramin is a nonsteroidal anti-inflammatory drug that binds to the ryanodine receptor, which is an intracellular calcium channel. It prevents the release of calcium from the sarcoplasmic reticulum, leading to decreased production of reactive oxygen species and preventing cell death. Suramin has been shown to inhibit the growth of murine sarcoma virus in cells by inhibiting the synthesis of a protein called growth factor-β1 (GF-β1). This drug also inhibits glycol ethers, which are known carcinogens that can cause DNA damage in cancerous cells. Suramin has been shown to have an apoptosis pathway, which is a biological process by which cells self-destruct when they are no longer needed or have become damaged. The binding of suramin to polymerase chain reaction (PCR) can be used as a diagnostic tool for detecting cancer tissues. Suramin has also been shown to bind to dextran sulfate and natural compounds with similar

Formula: C₅₁H₄₀N₆O₂₃S₆

Purity: Min. 95%

Molecular weight: 1,297.3 g/mol

Ref: 3D-AAA14563