CAS 145-63-1: Suramin

Description: Suramin is a synthetic organic compound primarily known for its use as an antiparasitic agent, particularly in the treatment of African sleeping sickness caused by Trypanosoma brucei. It is classified as a polysulfonated naphthylurea and exhibits a complex structure featuring multiple sulfonate groups, which contribute to its solubility in water. Suramin functions by inhibiting various enzymes and disrupting cellular processes in parasites, thereby preventing their proliferation. The compound is administered intravenously due to its poor oral bioavailability. In addition to its antiparasitic properties, suramin has been investigated for potential applications in other medical conditions, including certain cancers and viral infections, although its use in these areas is less established. Suramin's pharmacokinetics involve a relatively long half-life, allowing for less frequent dosing. However, it can cause side effects, including allergic reactions and nephrotoxicity, necessitating careful monitoring during treatment. Overall, suramin remains an important compound in tropical medicine and pharmacology.

Formula: C₅₁H₄₀N₆O₂₃S₆

InChI: InChI=1S/C51H40N6O23S6/c1-25-9-11-29(49(60)54-37-13-15-41(83(69,70)71)35-21-33(81(63,64)65)23-43(45(35)37)85(75,76)77)19-39(25)56-47(58)27-5-3-7-31(17-27)52-51(62)53-32-8-4-6-28(18-32)48(59)57-40-20-30(12-10-26(40)2)50(61)55-38-14-16-42(84(72,73)74)36-22-34(82(66,67)68)24-44(46(36)38)86(78,79)80/h3-24H,1-2H3,(H,54,60)(H,55,61)(H,56,58)(H,57,59)(H2,52,53,62)(H,63,64,65)(H,66,67,68)(H,69,70,71)(H,72,73,74)(H,75,76,77)(H,78,79,80)

InChI key: InChIKey=FIAFUQMPZJWCLV-UHFFFAOYSA-N

SMILES: O=C(NC1=CC=CC(=C1)C(=O)NC2=CC(=CC=C2C)C(=O)NC3=CC=C(C4=CC(=CC(=C34)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)NC5=CC=CC(=C5)C(=O)NC6=CC(=CC=C6C)C(=O)NC7=CC=C(C8=CC(=CC(=C78)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O

Synonyms:

• Farma 939
• 1,3,5-Naphthalenetrisulfonic acid, 8,8′-[ureylenebis[m-phenylenecarbonylimino(4-methyl-m-phenylene)carbonylimino]]di-
• Farma
• 8,8′-[Carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bis[1,3,5-naphthalenetrisulfonic acid]
• 1,3,5-Naphthalenetrisulfonic acid, 8,8′-[carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bis-

1,3,5-Naphthalenetrisulfonic acid, 8,8'-[carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bis-

CAS: 145-63-1

• Formula: C₅₁H₄₀N₆O₂₃S₆
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 1297.2797

Suramin

CAS: 145-63-1

Suramin is an RdRp and PTPase inhibitor with anti-parasitic, anti-tumor, and anti-angiogenic activities, inhibiting sirtuins …

• Formula: C₅₁H₄₀N₆O₂₃S₆
• Color and Shape: Liquid
• Molecular weight: 1297.28

Suramin

CAS: 145-63-1

Please enquire for more information about Suramin including the price, delivery time and more detailed …

• Formula: C₅₁H₄₀N₆O₂₃S₆
• Purity: Min. 95%
• Molecular weight: 1,297.3 g/mol