CAS 145017-83-0

ω-Agatoxin IVA

Description:

ω-Agatoxin IVA is a peptide toxin derived from the venom of the spider species *Agelenopsis aperta*, commonly known as the funnel-web spider. This compound is classified as a selective blocker of P/Q-type voltage-gated calcium channels, which play a crucial role in neurotransmitter release and muscle contraction. The structure of ω-Agatoxin IVA consists of a cyclic peptide framework, which contributes to its stability and specificity in binding to calcium channels. Its mechanism of action involves the inhibition of calcium ion influx, thereby affecting synaptic transmission and potentially leading to neurotoxic effects. Due to its selective nature, ω-Agatoxin IVA is often used in neurobiological research to study calcium channel function and the physiological processes influenced by calcium signaling. Additionally, its unique properties make it a subject of interest for potential therapeutic applications in conditions related to calcium channel dysfunction. However, its use is primarily confined to research settings due to its toxic nature.

Formula: C₂₁₇H₃₆₀N₆₈O₆₀S₁₀

Synonyms:

• Glu-Asp-Asn-Cys-Ile-Ala-Glu-Asp-Tyr-Gly-Lys-Cys-Thr-Trp-Gly-Gly-Thr-Lys-Cys-Cys-Arg-Gly-Arg-Pro-Cys-Arg-Cys-Ser-Met-Ile-Gly-Thr-Asn-Cys-Glu-Cys-Thr-Pro-Arg-Leu-Ile-Met-Glu-Gly-Leu-D-Ser-Phe-Ala
• Omega-Aga-Ivb
• Omega-Aga-Tk
• Omega-Agatoxin Tk (P-Type Blocker)
• Omega-Agatoxin Tk, Agelenopsis Aperta
• Snx 290
• Ω-Aga-Tk
• Ω-Agatoxin Tk
• ω-Aga-IV A
• ω-Agatoxin IV A (funnel-web spider venom)
• ω-Agatoxin IVA

ω-Agatoxin IVa

CAS: 145017-83-0

ω-Agatoxin IVa is a peptide isolated from the venom of the American funnel web spider, Agelenopsis aperta. ω-Aga IVa is a selective and potent blocker of the mammalian P-type voltage-dependent calcium channel.

Formula: C₂₁₇H₃₆₀N₆₈O₆₀S₁₀

Purity: > 95%

Color and Shape: Whitish Powder

Molecular weight: 5202.33

Ref: 01-4030173

ω-Agatoxin IVA

CAS: 145017-83-0

Selective blocker of P-type calcium channels (IC50 < 1 - 3 nM). Also inhibits N-type channels at micromolar concentrations.

Formula: C₂₁₇H₃₆₀N₆₈O₆₀S₁₀

Purity: 98%

Color and Shape: Solid

Molecular weight: 5202.25

Ref: TM-TP2087

ω-Agatoxin TK

CAS: 145017-83-0

Formula: C₂₁₅H₃₃₇N₆₅O₇₀S₁₀

Molecular weight: 5273.02

Ref: 7W-GK1357

ω-Agatoxin IVa

CAS: 145017-83-0

ω-Agatoxin IVa

Ref: 54-BIBA1037

ω-Agatoxin TK

CAS: 145017-83-0

A synthetic spider toxin, sourced from the Funnel Web Spider, Agelenopsis aperta. This toxin can be applied as a P-type Ca2+ channel selective blocker and has disulfide bonds between Cys4-Cys20, Cys12-Cys25,Cys19-Cys36 and Cys27-Cys34. This product is available as a 0.1mg vial.

Formula: C₂₁₅H₃₃₇N₆₅O₇₀S₁₀

Purity: Min. 95%

Molecular weight: 5,273 g/mol

Ref: 3D-PAG-4294-S

ω-agatoxin-IVA

CAS: 145017-83-0

Blocker of P/Q-type calcium channel (Cav2.1)

Ref: 3D-PP51213

ω-Agatoxin IVa trifluoroacetate

CAS: 145017-83-0

Omega-agatoxin IVa trifluoroacetate is a neurotoxin that inhibits voltage-dependent calcium channels. It blocks the opening of these channels, leading to an increase in cytosolic calcium. This toxin has been shown to be effective in treating autoimmune diseases and also has shown antimicrobial effects against bacteria. Omega-agatoxin IVa trifluoroacetate has a pathogenic mechanism that involves the inhibition of neuronal death by glutamate through its ability to block the release of glutamate from the presynaptic neuron. This toxin also binds to cerebellar Purkinje neurons and prevents them from firing, which leads to paralysis. Omega-agatoxin IVa trifluoroacetate is a glycosylated peptide with a disulfide bond that can be isolated using preparative high performance liquid chromatography (HPLC).

Formula: C₂₁₇H₃₆₀N₆₈O₆₀S₁₀

Purity: Min. 95%

Molecular weight: 5,202.26 g/mol

Ref: 3D-FA108461