CAS 145040-37-5: Candesartan cilexetil
Description:Candesartan cilexetil is an angiotensin II receptor antagonist primarily used in the treatment of hypertension and heart failure. It is a prodrug that is converted into its active form, candesartan, after oral administration. The substance is characterized by its ability to selectively block the angiotensin II type 1 receptor, which plays a crucial role in regulating blood pressure and fluid balance. Candesartan cilexetil is typically administered in tablet form and is known for its long half-life, allowing for once-daily dosing. Its chemical structure includes a biphenyl moiety and a tetrazole ring, contributing to its pharmacological properties. The compound is generally well-tolerated, with common side effects including dizziness and fatigue. Additionally, it has been shown to have beneficial effects on renal function and cardiovascular outcomes, making it a valuable option in managing patients with hypertension and related conditions. As with any medication, it is important for patients to consult healthcare professionals for personalized advice and monitoring.
Formula:C33H34N6O6
InChI:InChI=1S/C33H34N6O6/c1-3-42-32-34-28-15-9-14-27(31(40)43-21(2)44-33(41)45-24-10-5-4-6-11-24)29(28)39(32)20-22-16-18-23(19-17-22)25-12-7-8-13-26(25)30-35-37-38-36-30/h7-9,12-19,21,24H,3-6,10-11,20H2,1-2H3,(H,35,36,37,38)
InChI key:InChIKey=GHOSNRCGJFBJIB-UHFFFAOYSA-N
SMILES:O=C(OC(OC(=O)C1=CC=CC=2N=C(OCC)N(C21)CC=3C=CC(=CC3)C=4C=CC=CC4C5=NN=NN5)C)OC6CCCCC6
- Synonyms:
- (±)-1-Hydroxyethyl 2-ethoxy-1-[p-(o-1H-tetrazol-5-ylphenyl)l]-7-benzimidazolecarboxylate, cyclohexyl carbonate (ester)
- 1-Cyclohexyloxycarbonyloxyethyl 2-ethoxy-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylate
- 1-[[(Cyclohexyloxy)carbonyl]oxy]ethyl 2-ethoxy-1-([4-[2-(1H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl]methyl)-1H-1,3-benzodiazole-7-carboxylate
- 1-[[(Cyclohexyloxy)carbonyl]oxy]ethyl 2-ethoxy-1-[[2′-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate
- 1-[[(cyclohexyloxy)carbonyl]oxy]ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylate
- 1H-Benzimidazole-7-carboxylic acid, 2-ethoxy-1-[[2′-(1H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-, 1-[[(cyclohexyloxy)carbonyl]oxy]ethyl ester
- 1H-Benzimidazole-7-carboxylic acid, 2-ethoxy-1-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-, 1-[[(cyclohexyloxy)carbonyl]oxy]ethyl ester
- 2-Ethoxy-1-[(2′-(1H-tetrazol-5-yl)-1,1′-biphenyl-4-yl)methyl]-7-benzimidazolecarboxylic acid 1-(cyclohexyloxycarbonyloxy)ethyl ester
- Atacand
- Blopress
- See more synonyms
- Tcv 116
- Tcy 116
