CAS 145040-37-5

Candesartan cilexetil

Description:

Candesartan cilexetil is an angiotensin II receptor antagonist primarily used in the treatment of hypertension and heart failure. It is a prodrug that is converted into its active form, candesartan, after oral administration. The substance is characterized by its ability to selectively block the angiotensin II type 1 receptor, which plays a crucial role in regulating blood pressure and fluid balance. Candesartan cilexetil is typically administered in tablet form and is known for its long half-life, allowing for once-daily dosing. Its chemical structure includes a biphenyl moiety and a tetrazole ring, contributing to its pharmacological properties. The compound is generally well-tolerated, with common side effects including dizziness and fatigue. Additionally, it has been shown to have beneficial effects on renal function and cardiovascular outcomes, making it a valuable option in managing patients with hypertension and related conditions. As with any medication, it is important for patients to consult healthcare professionals for personalized advice and monitoring.

Formula: C₃₃H₃₄N₆O₆

InChI: InChI=1S/C33H34N6O6/c1-3-42-32-34-28-15-9-14-27(31(40)43-21(2)44-33(41)45-24-10-5-4-6-11-24)29(28)39(32)20-22-16-18-23(19-17-22)25-12-7-8-13-26(25)30-35-37-38-36-30/h7-9,12-19,21,24H,3-6,10-11,20H2,1-2H3,(H,35,36,37,38)

InChI key: InChIKey=GHOSNRCGJFBJIB-UHFFFAOYSA-N

SMILES: C(N1C=2C(N=C1OCC)=CC=CC2C(OC(OC(OC3CCCCC3)=O)C)=O)C4=CC=C(C=C4)C5=C(C=CC=C5)C=6NN=NN6

Synonyms:

• (±)-1-Hydroxyethyl 2-ethoxy-1-[p-(o-1H-tetrazol-5-ylphenyl)l]-7-benzimidazolecarboxylate, cyclohexyl carbonate (ester)
• 1-Cyclohexyloxycarbonyloxyethyl 2-ethoxy-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylate
• 1-[[(Cyclohexyloxy)carbonyl]oxy]ethyl 2-ethoxy-1-([4-[2-(1H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl]methyl)-1H-1,3-benzodiazole-7-carboxylate
• 1-[[(Cyclohexyloxy)carbonyl]oxy]ethyl 2-ethoxy-1-[[2′-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate
• 1-[[(cyclohexyloxy)carbonyl]oxy]ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylate
• 1H-Benzimidazole-7-carboxylic acid, 2-ethoxy-1-[[2′-(1H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-, 1-[[(cyclohexyloxy)carbonyl]oxy]ethyl ester
• 1H-Benzimidazole-7-carboxylic acid, 2-ethoxy-1-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-, 1-[[(cyclohexyloxy)carbonyl]oxy]ethyl ester
• 2-Ethoxy-1-[(2′-(1H-tetrazol-5-yl)-1,1′-biphenyl-4-yl)methyl]-7-benzimidazolecarboxylic acid 1-(cyclohexyloxycarbonyloxy)ethyl ester
• Atacand
• Blopress
• Tcv 116

Candesartan Cilexetil

CAS: 145040-37-5

Formula: C₃₃H₃₄N₆O₆

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 610.67

Ref: 3B-C2635

CANDESARTAN CILEXETIL CRS

CAS: 145040-37-5

CANDESARTAN CILEXETIL CRS

Formula: C₃₃H₃₄N₆O₆

Color and Shape: Powder

Molecular weight: 610.6597

Ref: 41-Y0001388

CANDESARTAN CILEXETIL FOR SYSTEM SUITABILITY CRS

CAS: 145040-37-5

CANDESARTAN CILEXETIL FOR SYSTEM SUITABILITY CRS

Formula: C₃₃H₃₄N₆O₆

Color and Shape: Powder

Molecular weight: 610.6597

Ref: 41-Y0001389

Candesartan cilexetil

CAS: 145040-37-5

Candesartan cilexetil

Formula: C₃₃H₃₄N₆O₆

Purity: 99.6%

Color and Shape: Off-White

Molecular weight: 610.25398

Ref: 47-1248

CANDESARTAN CILEXETIL FOR PEAK IDENTIFICATION CRS

CAS: 145040-37-5

CANDESARTAN CILEXETIL FOR PEAK IDENTIFICATION CRS

Formula: C₃₃H₃₄N₆O₆

Color and Shape: Powder

Molecular weight: 610.6597

Ref: 41-Y0001387

Candesartan cilexetil impurity standard

CAS: 1185256-03-4, 145040-37-5

Candesartan cilexetil impurity standard

Color and Shape: Off-White

Ref: 47-1249

Candesartan Cilexetil

CAS: 145040-37-5

Cardiovascular drugs, nesoi

Formula: C₃₃H₃₄N₆O₆

Color and Shape: White Off-White Crystalline Powder

Molecular weight: 610.25398

Ref: 45-1087803

Candesartan Cilexetil

CAS: 145040-37-5

Formula: C₃₃H₃₄N₆O₆

Color and Shape: White To Off-White Solid

Molecular weight: 610.67

Ref: 4Z-C-015

Candesartan cilexetil

CAS: 145040-37-5

Candesartan cilexetil

Purity: 99%+

Molecular weight: 610.66g/mol

Ref: 54-OR1028278

Candesartan Cilexetil

CAS: 145040-37-5

Candesartan Cilexetil

Purity: ≥98%

Molecular weight: 610.66g/mol

Ref: 54-BUP18380

Candesartan cilexetil

CAS: 145040-37-5

Formula: C₃₃H₃₄N₆O₆

Purity: ≥ 98.0%

Color and Shape: White to off-white or beige powder

Molecular weight: 610.66

Ref: 7W-GP6212

Candesartan Cilexetil

CAS: 145040-37-5

Color and Shape: Neat

Ref: 61-FOR0776.00

Candesartan Cilexetil

CAS: 145040-37-5

Color and Shape: Neat

Ref: 86-MM0776.00

Candesartan cilexetil

Controlled Product

CAS: 145040-37-5

Formula: C₃₃H₃₄N₆O₆

Color and Shape: Neat

Molecular weight: 610.66

Ref: 04-C10945530

Candesartan Cilexetil

CAS: 145040-37-5

Candesartan Cilexetil, an angiotensin II blocker (IC50: 0.26 nM), turns to candesartan in the body, which dilates blood vessels by hindering AT1.

Formula: C₃₃H₃₄N₆O₆

Purity: 98.22% - >99.99%

Color and Shape: White Crystalline Powder

Molecular weight: 610.66

Ref: TM-T2400

Candesartan Cilexetil

Controlled Product

CAS: 145040-37-5

Applications Ester prodrug; hydrolized in vivo to the active carboxylic acid. Used in treatment of congestive heart failure. Antihypertensive. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Shibouta, Y., et al.: J. Pharmacol. Exp. Ther., 266, 114 (1993), Ogihara, T., et al.: Clin. Ther., 16, 74 (1994)

Formula: C₃₃H₃₄N₆O₆

Color and Shape: Off-White

Molecular weight: 610.66

Ref: TR-C175580

Candesartan cilexetil - Bio-X ™

CAS: 145040-37-5

Candesartan is an anti-hypertensive drug used in the treatment of hypertension. This drug is an antagonist of the GPCR angiotensin II receptor I and works to relax smooth muscles and lower blood pressure. Candesartan cilexetil is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready-to-use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Formula: C₃₃H₃₄N₆O₆

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 610.66 g/mol

Ref: 3D-BC164274

Candesartan cilexetil

CAS: 145040-37-5

Prodrug of candesartan; angiotensin II receptor I antagonist

Formula: C₃₃H₃₄N₆O₆

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 610.66 g/mol

Ref: 3D-FC19661

Candesartan Cilexetil N-Trityl Nitro Analogue

Controlled Product

CAS: 145040-37-5

Formula: C₅₄H₅₂N₆O₉

Color and Shape: Neat

Molecular weight: 929.025

Ref: TR-C175586