CAS 145165-10-2

1-hydroxyoxaunomycin

Description:

1-Hydroxyoxaunomycin is a chemical compound that belongs to the class of natural products known as anthracyclines, which are primarily recognized for their use in cancer therapy due to their ability to intercalate DNA and inhibit topoisomerase II. This compound features a unique structure characterized by a hydroxyl group (-OH) attached to the oxo group in its molecular framework, which contributes to its biological activity. The presence of the hydroxy group can enhance its solubility and influence its pharmacokinetic properties. 1-Hydroxyoxaunomycin exhibits cytotoxic effects against various cancer cell lines, making it a subject of interest in medicinal chemistry and drug development. Its mechanism of action involves the generation of reactive oxygen species and the induction of apoptosis in cancer cells. Additionally, the compound's stability, bioavailability, and potential side effects are important considerations in its therapeutic application. Ongoing research aims to further elucidate its efficacy and safety profile in clinical settings.

Formula: C₂₆H₂₉NO₁₁

InChI: InChI=1/C26H29NO11/c1-3-26(36)7-12(38-13-6-9(27)20(30)8(2)37-13)16-19(25(26)35)24(34)18-17(23(16)33)21(31)14-10(28)4-5-11(29)15(14)22(18)32/h4-5,8-9,12-13,20,25,28-30,33-36H,3,6-7,27H2,1-2H3

Synonyms:

• 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-8-ethyl-7,8,9,10-tetrahydro-1,4,6,7,8,11-hexahydroxy-, [7R-(7α,8β,10β)]-
• 1-hydroxyoxaunomycin
• 1-Hydroxy-D788-7
• 3-ethyl-3,4,5,7,10,12-hexahydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxyhexopyranoside
• 5,12-Naphthacenedione, 10-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-8-ethyl-7,8,9,10-tetrahydro-1,4,6,7,8,11-hexahydroxy-, (7R-(7alpha,8beta,10beta))-
• 1-Hydroxyoxaunomycin
• 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-8-ethyl-7,8,9,10-tetrahydro-1,4,6,7,8,11-hexahydroxy-, [7R-(7α,8β,10β)]- (9CI)

1-Hydroxyoxaunomycin

CAS: 145165-10-2

1-Hydroxyoxaunomycin is an antibiotic that inhibits the growth of U210 cells as well as the synthesis of DNA and RNA, with IC50 values of 0.0005 μg/mL, 1.00 μg/mL, and 0.76 μg/mL, respectively.

Formula: C₂₆H₂₉NO₁₁

Color and Shape: Solid

Molecular weight: 531.509

Ref: TM-TN9866