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(Z)-Entacapone

CAS 145195-63-7: (Z)-Entacapone

Description:(Z)-Entacapone is a chemical compound primarily used as a medication to treat Parkinson's disease, functioning as a catechol-O-methyltransferase (COMT) inhibitor. This compound enhances the effectiveness of levodopa by preventing its breakdown, thereby increasing its availability in the brain. The molecular structure of (Z)-Entacapone features a specific geometric configuration, indicated by the (Z) designation, which refers to the arrangement of substituents around a double bond. It is characterized by its ability to form hydrogen bonds due to the presence of hydroxyl groups, contributing to its solubility in polar solvents. The compound exhibits moderate lipophilicity, allowing it to cross biological membranes effectively. In terms of safety, (Z)-Entacapone has been associated with various side effects, including gastrointestinal disturbances and dyskinesia, which are important considerations in its therapeutic use. Overall, (Z)-Entacapone plays a significant role in the management of Parkinson's disease symptoms, improving patients' quality of life when used in conjunction with other dopaminergic therapies.

Formula:C14H15N3O5

InChI:InChI=1S/C14H15N3O5/c1-3-16(4-2)14(20)10(8-15)5-9-6-11(17(21)22)13(19)12(18)7-9/h5-7,18-19H,3-4H2,1-2H3/b10-5-

InChI key:InChIKey=JRURYQJSLYLRLN-YHYXMXQVSA-N

SMILES:N#CC(=CC1=CC(O)=C(O)C(=C1)N(=O)=O)C(=O)N(CC)CC

  • Synonyms:
  • (2Z)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide
  • (Z)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide
  • (Z)-Entacapone
  • 2-Propenamide, 2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-, (2Z)-
  • 2-Propenamide, 2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-, (Z)-
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Found 8 products.

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Ref: 45-1235944

25mg1,371.00 €
Estimated delivery in United States, on Tuesday 11 Mar 2025
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Ref: 4Z-E-032

5mgTo inquire
10mgTo inquire
25mgTo inquire
50mgTo inquire
100mgTo inquire
Estimated delivery in United States, on Tuesday 11 Mar 2025
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(2Z)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylprop-2-enamide

Controlled Product
CAS:145195-63-7

Ref: 86-MM1221.02-0025

25mg215.00 €
Estimated delivery in United States, on Thursday 13 Mar 2025
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Entacapone Related Substance A for SS RS

CAS:145195-63-7

Ref: 2K-1031830021

10mgTo inquire
Estimated delivery in United States, on Tuesday 18 Mar 2025
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cis-Entacapone

Controlled Product
CAS:145195-63-7

Ref: TR-E558490

10mg612.00 €
50mg2,212.00 €
Estimated delivery in United States, on Thursday 20 Mar 2025
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cis-Entacapone-d10

Controlled Product
CAS:145195-63-7

Ref: TR-E558492

1mg282.00 €
10mg1,899.00 €
Estimated delivery in United States, on Tuesday 22 Apr 2025
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cis-Entacapone

CAS:145195-63-7

Ref: TM-T70608

5mg1,074.00 €
Estimated delivery in United States, on Monday 28 Apr 2025
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cis-Entacapone

Controlled Product
CAS:145195-63-7

Ref: 3D-FE22677

1mgDiscontinuedRequest information
2mgDiscontinuedRequest information
5mgDiscontinuedRequest information
10mgDiscontinuedRequest information
25mgDiscontinuedRequest information
Discontinued product
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