CAS 145216-43-9

Forasartan

Description:

Forasartan is an angiotensin II receptor antagonist primarily used in the treatment of hypertension. It belongs to the class of medications known as sartans, which work by blocking the action of angiotensin II, a hormone that causes blood vessels to constrict, thereby lowering blood pressure. Forasartan is characterized by its ability to selectively inhibit the AT1 receptor, leading to vasodilation and reduced blood pressure. The compound is typically administered orally and is known for its relatively long half-life, allowing for once-daily dosing. In terms of its chemical structure, Forasartan features a biphenyl moiety and a carboxylic acid group, contributing to its pharmacological properties. It is generally well-tolerated, with a side effect profile similar to other medications in its class, including dizziness, fatigue, and potential renal effects. As with any antihypertensive medication, monitoring of blood pressure and renal function is recommended during treatment.

Formula: C₂₃H₂₈N₈

InChI: InChI=1S/C23H28N8/c1-3-5-11-21-25-22(12-6-4-2)31(28-21)16-17-13-14-20(24-15-17)18-9-7-8-10-19(18)23-26-29-30-27-23/h7-10,13-15H,3-6,11-12,16H2,1-2H3,(H,26,27,29,30)

InChI key: InChIKey=YONOBYIBNBCDSJ-UHFFFAOYSA-N

SMILES: C(C1=CC=C(C2=C(C=CC=C2)C=3NN=NN3)N=C1)N4C(CCCC)=NC(CCCC)=N4

Synonyms:

• Pyridine, 5-[(3,5-dibutyl-1H-1,2,4-triazol-1-yl)methyl]-2-[2-(2H-tetrazol-5-yl)phenyl]-
• Pyridine, 5-[(3,5-dibutyl-1H-1,2,4-triazol-1-yl)methyl]-2-[2-(1H-tetrazol-5-yl)phenyl]-
• Forasartan
• 5-[(3,5-Dibutyl-1H-1,2,4-triazol-1-yl)methyl]-2-[2-(2H-tetrazol-5-yl)phenyl]pyridine
• SC 52458

Forasartan

CAS: 145216-43-9

Forasartan is an antihypertensive that blocks AT1 receptors to prevent vasoconstriction and aldosterone synthesis.

Formula: C₂₃H₂₈N₈

Color and Shape: Solid

Molecular weight: 416.52

Ref: TM-T31845

Forasartan

Controlled Product

CAS: 145216-43-9

Applications Forasartan is a novel angiotensin (AII) receptor antagonist with antihypertensive effects.
References Mcmahon, E.G., et al.: Am. J. Hypertens., 10, 671 (1997); Hagmann, M., et al.: J. Cardiovasc. Pharm., 29, 444 (1997); Olins, G.M., et al.: J. Cardiovasc. Pharm., 22, 617 (1993)

Formula: C₂₃H₂₈N₈

Color and Shape: Neat

Molecular weight: 416.522

Ref: TR-F685000

Forasartan

CAS: 145216-43-9

Forasartan is a protein target and enzyme inhibitor that has been used for the treatment of cardiac disease and hypertension. Forasartan is a potent inhibitor of angiotensin II, a major pressor hormone that promotes vasoconstriction, and prevents the formation of angiotensin II from angiotensin I. Forasartan also blocks the production of angiotensin II by blocking the activity of renin, an enzyme involved in the production of angiotensin I. The drug has been shown to be effective against congestive heart failure and high blood pressure. Forasartan has also been shown to inhibit growth factor-β1, which can lead to cell death. Forasartan is eliminated through metabolism by 2-aminoethoxydiphenyl borate (2-APB). This metabolic pathway produces metabolites such as N-demethylforasartan and 2-APB sulfoxide (2-APBS), which

Formula: C₂₃H₂₈N₈

Purity: Min. 95%

Molecular weight: 416.52 g/mol

Ref: 3D-FF168409