CAS 145350-09-0

Pioglitazone Hydrochloride

Description:

Pioglitazone Hydrochloride is an antidiabetic medication primarily used to manage type 2 diabetes mellitus. It belongs to the thiazolidinedione class of drugs, which function as agonists of the peroxisome proliferator-activated receptor gamma (PPAR-γ). This action enhances insulin sensitivity in muscle and adipose tissue, thereby improving glucose uptake and utilization. The substance appears as a white to off-white crystalline powder, and it is soluble in water and methanol, which facilitates its formulation in various dosage forms. Pioglitazone Hydrochloride is typically administered orally and is often prescribed in conjunction with diet and exercise to achieve better glycemic control. Common side effects may include weight gain, edema, and an increased risk of heart failure, necessitating careful patient monitoring. Additionally, it has been associated with potential risks of bladder cancer, leading to specific recommendations regarding its use. Overall, Pioglitazone Hydrochloride plays a significant role in diabetes management, particularly for patients who are insulin-resistant.

Formula: C₁₉H₂₀N₂O₃S・HCl

InChI: InChI=1S/C19H20N2O3S.ClH/c1-2-13-3-6-15(20-12-13)9-10-24-16-7-4-14(5-8-16)11-17-18(22)21-19(23)25-17;/h3-8,12,17H,2,9-11H2,1H3,(H,21,22,23);1H

SMILES: CCc1ccc(CCOc2ccc(cc2)CC2C(=NC(=O)S2)O)nc1.Cl

Synonyms:

• Pioglitazone HCl
• 5-[[4-[2-(5-Ethyl-2-pyridinyl]ethoxy]phenyl]methyl]-2,4-thiazolidinedione N-Oxide
• Pioglitazone N-Oxide
• 5-{4-[2-(5-Ethyl-1-Oxidopyridin-2-Yl)Ethoxy]Benzyl}-1,3-Thiazolidine-2,4-Dione
• 5-[[4-2-(5-ethyl-2-pyridinyl)ethoxy]benzylidene]-2,4-thiazolidinedione Hydrochloride
• [5-[[4-[2-(5-Ethyl-2-Pyridinyl)Ethoxy]Phenyl]Methyl]-2,4-] Thiazolidinedione Hydrochloride

Pioglitazone N-Oxide

CAS: 145350-09-0

Formula: C₁₉H₂₀N₂O₄S

Color and Shape: Solid

Molecular weight: 372.4381

Ref: IN-DA001KTL

Pioglitazone N-Oxide

CAS: 145350-09-0

Formula: C₁₉H₂₀N₂O₄S

Color and Shape: White To Off-White Solid

Molecular weight: 372.44

Ref: 4Z-P-107

Pioglitazone N-Oxide

CAS: 145350-09-0

Color and Shape: Neat

Ref: 86-MM0616.09

Pioglitazone N-Oxide

CAS: 145350-09-0

Formula: C₁₉H₂₀N₂O₄S

Molecular weight: 372.44

Ref: ST-EA-CP-P7015

Pioglitazone N-Oxide

Controlled Product

CAS: 145350-09-0

Applications A metabolite of Pioglitazone (P471000).
References Tanis, S.P., et al.: J. Med. Chem., 39, 5053 (1999)

Formula: C₁₉H₂₀N₂O₄S

Color and Shape: Neat

Molecular weight: 372.44

Ref: TR-P471010