CAS 145416-34-8

2(1H)-Pyrimidinone,4-amino-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-, (2S-trans)- (9CI)

Description:

2(1H)-Pyrimidinone, 4-amino-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-, (2S-trans)- is a chemical compound characterized by its pyrimidinone core structure, which features a fluorine atom and an amino group at specific positions on the ring. The presence of the oxathiolane moiety indicates that it contains a sulfur atom within a five-membered ring, contributing to its unique properties and potential biological activity. This compound is often studied for its relevance in medicinal chemistry, particularly in the development of antiviral or anticancer agents. Its stereochemistry, indicated by the (2S-trans) designation, suggests specific spatial arrangements that can influence its interaction with biological targets. The CAS number 145416-34-8 serves as a unique identifier for this substance, facilitating its recognition in scientific literature and databases. Overall, this compound exemplifies the complexity of heterocyclic chemistry and its applications in drug design and development.

Formula: C₈H₁₀FN₃O₃S

Synonyms:

• 1,3-Oxathiolane,2(1H)-pyrimidinone deriv.

2-epi-Emtricitabine

CAS: 145416-34-8

Formula: C₈H₁₀FN₃O₃S

Color and Shape: White To Off-White Solid

Molecular weight: 247.24

Ref: 4Z-E-588

2-epi-(-)-emtricitabine

CAS: 145416-34-8

Ref: 7W-GC4103

2-Epi-Emtricitabine

CAS: 145416-34-8

Formula: C₈H₁₀FN₃O₃S

Molecular weight: 247.3

Ref: ST-EA-CP-E5016

2-epi-Emtricitabine

CAS: 145416-34-8

Applications The 2-epi-enantiomer analogue of (-)-Emtricitabine (E525000) evaluated against HIV-1 in human peripheral blood mononuclear (PBM) cells.
References Jeong, L.S., et al.: J. Med. Chem., 36, 2627 (1993),

Formula: C₈H₁₀FN₃O₃S

Color and Shape: Off White Solid

Molecular weight: 247.25

Ref: TR-E524990

Emtricitabine 2-Epimer (4-amino-5-fluoro-1-((2S,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)pyrimidin-2(1H)-one; 5-Fluoro-1-[(2S,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine)

CAS: 145416-34-8

Nucleic acids and their salts, whether or not chemically defined; other heterocyclic compounds, nesoi

Formula: C₈H₁₀FN₃O₃S

Color and Shape: Off-White Solid

Molecular weight: 247.04269

Ref: 45-1A04610

2-epi-(-)-emtricitabine

CAS: 145416-34-8

2-epi-(-)-emtricitabine is an analog of the nucleoside cytidine, which inhibits the phosphorylation and subsequent degradation of deoxycytidine kinase, thereby blocking the production of the viral DNA polymerase. The compound also inhibits tyrosine kinases, which are enzymes that play a vital role in cell signaling. This inhibition may contribute to its antiviral activity. 2-epi-(-)-emtricitabine has been shown to inhibit human immunodeficiency virus (HIV) replication in vitro and in vivo. It is a prodrug that is converted to emtricitabine, its active form, by deoxycytidine kinase and then hydrolyzed by esterases. 2-epi-(-)-emtricitabine has been shown to be effective against hepatitis B virus and cancer cells.

Formula: C₈H₁₀FN₃O₃S

Purity: Min. 95%

Molecular weight: 247.25 g/mol

Ref: 3D-ME16711