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CAS 145455-35-2

:

L-692,585

Description:
L-692,585, with the CAS number 145455-35-2, is a chemical compound that belongs to the class of selective inhibitors, specifically targeting the enzyme 5-lipoxygenase (5-LO). This compound is notable for its potential therapeutic applications, particularly in the treatment of inflammatory diseases and conditions related to leukotriene synthesis. L-692,585 exhibits a high degree of selectivity for 5-LO, which is crucial for minimizing side effects associated with non-selective inhibitors. The compound's structure includes specific functional groups that contribute to its binding affinity and inhibitory action. In preclinical studies, L-692,585 has demonstrated efficacy in reducing inflammation and modulating immune responses, making it a subject of interest in pharmacological research. Its safety profile and pharmacokinetics are also important considerations for potential clinical applications. Overall, L-692,585 represents a significant advancement in the development of targeted therapies for conditions driven by leukotriene-mediated pathways.
Formula:C32H37N7O3
InChI:InChI=1/C32H37N7O3/c1-21(40)19-33-32(2,3)18-29(41)34-27-17-16-24-8-4-7-11-28(24)39(31(27)42)20-22-12-14-23(15-13-22)25-9-5-6-10-26(25)30-35-37-38-36-30/h4-15,21,27,33,40H,16-20H2,1-3H3,(H,34,41)(H,35,36,37,38)/t21-,27-/m1/s1
SMILES:C[C@H](CNC(C)(C)CC(=N[C@@H]1CCc2ccccc2N(Cc2ccc(cc2)c2ccccc2c2n[nH]nn2)C1=O)O)O
Synonyms:
  • 3-{[(2R)-2-Hydroxypropyl]amino}-3-methyl-N-[(3R)-2-oxo-1-{[2'-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl}-2,3,4,5-tetrahydro-1H-1-benzazepin-3-yl]butanamide
  • Butanamide, 3-[[(2R)-2-hydroxypropyl]amino]-3-methyl-N-[(3R)-2,3,4,5-tetrahydro-2-oxo-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-1-benzazepin-3-yl]-
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