CAS 1454846-35-5: (10R)-7-Amino-12-fluoro-10,15,16,17-tetrahydro-2,10,16-trimethyl-15-oxo-2H-4,8-methenopyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile

Description: The chemical substance known as (10R)-7-Amino-12-fluoro-10,15,16,17-tetrahydro-2,10,16-trimethyl-15-oxo-2H-4,8-methenopyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile, with the CAS number 1454846-35-5, is a complex organic compound characterized by its unique structural features, including multiple fused rings and functional groups. This compound contains an amino group, a fluorine atom, and a carbonitrile group, which contribute to its potential biological activity. The presence of the methenopyrazolo and benzoxadiazacyclotetradecine moieties suggests that it may exhibit interesting pharmacological properties, possibly acting as a ligand or inhibitor in various biochemical pathways. Its stereochemistry, indicated by the (10R) designation, implies specific spatial arrangements that can influence its interactions with biological targets. Such compounds are often investigated for their potential therapeutic applications, particularly in fields like medicinal chemistry and drug development. However, detailed studies would be necessary to elucidate its specific properties, mechanisms of action, and potential uses in clinical settings.

Formula: C₂₁H₁₉FN₆O₂

InChI: InChI=1S/C21H19FN6O2/c1-11-15-7-13(22)4-5-14(15)21(29)27(2)10-16-19(17(8-23)28(3)26-16)12-6-18(30-11)20(24)25-9-12/h4-7,9,11H,10H2,1-3H3,(H2,24,25)/t11-/m1/s1

InChI key: InChIKey=IIXWYSCJSQVBQM-LLVKDONJSA-N

SMILES: N#CC1=C2C3=CN=C(N)C(OC(C4=CC(F)=CC=C4C(=O)N(C)CC2=NN1C)C)=C3

Synonyms:

• (10R)-7-Amino-12-fluoro-10,15,16,17-tetrahydro-2,10,16-trimethyl-15-oxo-2H-4,8-methenopyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile
• 2H-4,8-Methenopyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile, 7-amino-12-fluoro-10,15,16,17-tetrahydro-2,10,16-trimethyl-15-oxo-, (10R)-
• Loratinib
• Lorbrena
• Lorlatinib
• Lorviqua
• Pf0643922
• PF 06463922

2H-4,8-Methenopyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile, 7-amino-12-fluoro-10,15,16,17-tetrahydro-2,10,16-trimethyl-15-oxo-, (10R)-

CAS: 1454846-35-5

• Formula: C₂₁H₁₉FN₆O₂
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 406.413

Lorlatinib-13C-d3

CAS: 1454846-35-5

• Formula: C₂₀₁₃CH₁₆D₃FN₆O₂
• Molecular weight: 410.43

Lorlatinib (PF-6463922)

CAS: 1454846-35-5

• Formula: C₂₁H₁₉FN₆O₂
• Molecular weight: 406.42

Lorlatinib

CAS: 1454846-35-5

Lorlatinib (PF-6463922) is an orally available, ATP-competitive inhibitor of the receptor tyrosine kinases, anaplastic lymphoma …

• Formula: C₂₁H₁₉FN₆O₂
• Purity: 99.81% - 99.95%
• Color and Shape: Solid
• Molecular weight: 406.41

Lorlatinib

CAS: 1454846-35-5

Brain-penetrant inhibitor of anaplastic lymphoma kinase (ALK) and proto-oncogene kinase ROS1. It is a reversible …

• Formula: C₂₁H₁₉FN₆O₂
• Purity: Min. 95%
• Molecular weight: 406.41 g/mol

Lorlatinib (PF-6463922)

CAS: 1454846-35-5

• Formula: C₂₁H₁₉FN₆O₂
• Molecular weight: 406.42