CAS 1454846-35-5

(10R)-7-Amino-12-fluoro-10,15,16,17-tetrahydro-2,10,16-trimethyl-15-oxo-2H-4,8-methenopyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile

Description:

The chemical substance known as (10R)-7-Amino-12-fluoro-10,15,16,17-tetrahydro-2,10,16-trimethyl-15-oxo-2H-4,8-methenopyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile, with the CAS number 1454846-35-5, is a complex organic compound characterized by its unique structural features, including multiple fused rings and functional groups. This compound contains an amino group, a fluorine atom, and a carbonitrile group, which contribute to its potential biological activity. The presence of the methenopyrazolo and benzoxadiazacyclotetradecine moieties suggests that it may exhibit interesting pharmacological properties, possibly acting as a ligand or inhibitor in various biochemical pathways. Its stereochemistry, indicated by the (10R) designation, implies specific spatial arrangements that can influence its interactions with biological targets. Such compounds are often investigated for their potential therapeutic applications, particularly in fields like medicinal chemistry and drug development. However, detailed studies would be necessary to elucidate its specific properties, mechanisms of action, and potential uses in clinical settings.

Formula: C₂₁H₁₉FN₆O₂

InChI: InChI=1S/C21H19FN6O2/c1-11-15-7-13(22)4-5-14(15)21(29)27(2)10-16-19(17(8-23)28(3)26-16)12-6-18(30-11)20(24)25-9-12/h4-7,9,11H,10H2,1-3H3,(H2,24,25)/t11-/m1/s1

InChI key: InChIKey=IIXWYSCJSQVBQM-LLVKDONJSA-N

SMILES: C(#N)C1=C2C=3C=C(O[C@H](C)C=4C(C(=O)N(C)CC2=NN1C)=CC=C(F)C4)C(N)=NC3

Synonyms:

• (10R)-7-Amino-12-fluoro-10,15,16,17-tetrahydro-2,10,16-trimethyl-15-oxo-2H-4,8-methenopyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile
• 2H-4,8-Methenopyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile, 7-amino-12-fluoro-10,15,16,17-tetrahydro-2,10,16-trimethyl-15-oxo-, (10R)-
• Loratinib
• Lorbrena
• Lorlatinib
• Lorviqua
• Pf0643922
• PF 06463922
• Top quality 1454846-35-5 Lorlatinib (PF-06463922)
• Laura for,
• 13C,2H3]-Lorlatinib
• Lorlatinib Lorlatinib
• Loratinib (PF-06463922)
• CS-1727
• Laratinib
• Lorlatinib 13CD3
• DISCONTINUED
• EOS-60936
• PF-06463922, Lorlatinib
• Lauratinib
• (R)-26-amino-55-fluoro-11,4,7-trimethyl-6-oxo-11H-3-oxa-7-aza-2(3,5)-pyridina-1(4,3)-pyrazola-5(1,2)-benzenacyclooctaphane-15-carbonitrile
• PF6463922
• LAOLA TINI
• Lorlatinib?(PF-6463922)
• PF06463922; PF 06463922; PF-06463922; PF-6463922; PF6463922; PF 6463922; LORLATINIB; LORBRENA.
• ALK tyrosine kinase receptor,Anaplastic lymphoma kinase,tyrosine,Apoptosis,PF 06463922,inhibit,Neuroblastoma,Carcinoma,Anaplastic lymphoma kinase (ALK),NSCLC,Inhibitor,Lorlatinib,mutation,kinase,Cluster of differentiation 246,brain-penetrant,ROS Kinase,CD246,third-generation,PF06463922
• Anaplastic lymphoma kinase (ALK)
• PF 6463922
• Bromopropylate Impurity 15
• LORLATINIB API
• 140539
• lee011/inc280
• High Purity API Lorlatinib
• Lorlatinib(PF0643922)
• INC280INC280
• (10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]-benzoxadiazacyclotetradecine-3-carbonitrile
• PF-6463922
• Lorlatinib,PF-06463922
• PF06463922;PF-06463922;PF 06463922
• Lorlatinib Powder

2H-4,8-Methenopyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile, 7-amino-12-fluoro-10,15,16,17-tetrahydro-2,10,16-trimethyl-15-oxo-, (10R)-

CAS: 1454846-35-5

Formula: C₂₁H₁₉FN₆O₂

Purity: 99%

Color and Shape: Solid

Molecular weight: 406.4130

Ref: IN-DA001D3G

Lorlatinib (PF-6463922)

CAS: 1454846-35-5

Formula: C₂₁H₁₉FN₆O₂

Molecular weight: 406.42

Ref: 4Z-L-229001

Lorlatinib

CAS: 1454846-35-5

Lorlatinib

Purity: ≥98%

Molecular weight: 406.41g/mol

Ref: 54-BUP11605

Lorlatinib

CAS: 1454846-35-5

Lorlatinib (PF-6463922) is an orally available, ATP-competitive inhibitor of the receptor tyrosine kinases, anaplastic lymphoma kinase (ALK) and C-ros oncogene

Formula: C₂₁H₁₉FN₆O₂

Purity: 99.77% - 99.95%

Color and Shape: Solid

Molecular weight: 406.41

Ref: TM-T3061

Lorlatinib-13C-d3

CAS: 1454846-35-5

Formula: C₂₀₁₃CH₁₆D₃FN₆O₂

Molecular weight: 410.43

Ref: 4Z-L-229003

Lorlatinib

CAS: 1454846-35-5

Brain-penetrant inhibitor of anaplastic lymphoma kinase (ALK) and proto-oncogene kinase ROS1. It is a reversible ATP-competitor, interacting with P-loop (L1122, G1123, V1130) and K1150 residue of ALK tyrosine kinase. It has major implications in the treatment of non-small cell lung cancer (NSCLC). The compound is used for resensitization of drug resistant, ALK-mutated cancers to crizotinib chemotherapy and was shown to trigger the regression of EML40ALK-driven brain metastases.

Formula: C₂₁H₁₉FN₆O₂

Purity: Min. 95%

Molecular weight: 406.41 g/mol

Ref: 3D-FP104236

Lorlatinib

CAS: 1454846-35-5

Purity: 99%

Molecular weight: 406.421

Ref: 10-F979308