CAS 1454846-35-5: (10R)-7-Amino-12-fluoro-10,15,16,17-tetrahydro-2,10,16-trimethyl-15-oxo-2H-4,8-methenopyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile

Formula: C₂₁H₁₉FN₆O₂

InChI: InChI=1S/C21H19FN6O2/c1-11-15-7-13(22)4-5-14(15)21(29)27(2)10-16-19(17(8-23)28(3)26-16)12-6-18(30-11)20(24)25-9-12/h4-7,9,11H,10H2,1-3H3,(H2,24,25)/t11-/m1/s1

InChI key: InChIKey=IIXWYSCJSQVBQM-LLVKDONJSA-N

SMILES: N#CC1=C2C3=CN=C(N)C(OC(C4=CC(F)=CC=C4C(=O)N(C)CC2=NN1C)C)=C3

Synonyms:

• (10R)-7-Amino-12-fluoro-10,15,16,17-tetrahydro-2,10,16-trimethyl-15-oxo-2H-4,8-methenopyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile
• 2H-4,8-Methenopyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile, 7-amino-12-fluoro-10,15,16,17-tetrahydro-2,10,16-trimethyl-15-oxo-, (10R)-
• Loratinib
• Lorbrena
• Lorlatinib
• Lorviqua
• Pf0643922
• PF 06463922

2H-4,8-Methenopyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile, 7-amino-12-fluoro-10,15,16,17-tetrahydro-2,10,16-trimethyl-15-oxo-, (10R)-

CAS: 1454846-35-5

• Formula: C₂₁H₁₉FN₆O₂
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 406.4130

Lorlatinib-13C-d3

CAS: 1454846-35-5

• Formula: C₂₀₁₃CH₁₆D₃FN₆O₂
• Molecular weight: 410.43

Lorlatinib (PF-6463922)

CAS: 1454846-35-5

• Formula: C₂₁H₁₉FN₆O₂
• Molecular weight: 406.42

Lorlatinib

CAS: 1454846-35-5

Lorlatinib (PF-6463922) is an orally available, ATP-competitive inhibitor of the receptor tyrosine kinases, anaplastic lymphoma …

• Formula: C₂₁H₁₉FN₆O₂
• Purity: 99.81% - 99.82%
• Color and Shape: Solid
• Molecular weight: 406.41

Lorlatinib

CAS: 1454846-35-5

Brain-penetrant inhibitor of anaplastic lymphoma kinase (ALK) and proto-oncogene kinase ROS1. It is a reversible …

• Formula: C₂₁H₁₉FN₆O₂
• Purity: Min. 95%
• Molecular weight: 406.41 g/mol

Lorlatinib (PF-6463922)

CAS: 1454846-35-5

• Formula: C₂₁H₁₉FN₆O₂
• Molecular weight: 406.42