The chemical substance known as Urea, N-[2-fluoro-4-methyl-5-[2-methyl-7-(methylamino)-1,6-naphthyridin-3-yl]phenyl]-N′-[(2S)-2-hydroxy-3,3-dimethylbutyl]- (CAS 1455031-68-1) is a complex organic compound characterized by its urea functional group, which is central to its structure. This compound features a fluorinated aromatic ring and a naphthyridine moiety, contributing to its potential biological activity. The presence of a hydroxyl group on a branched alkyl chain suggests possible interactions with biological targets, enhancing its solubility and reactivity. The methylamino group indicates potential for hydrogen bonding, which may influence its pharmacokinetic properties. Overall, this compound's intricate structure may confer specific properties that could be relevant in medicinal chemistry, particularly in the development of pharmaceuticals targeting various biological pathways. Its unique combination of functional groups and structural features may also affect its stability, reactivity, and interaction with other molecules.

Urea, N-[2-fluoro-4-methyl-5-[2-methyl-7-(methylamino)-1,6-naphthyridin-3-yl]phenyl]-N′-[(2S)-2-hydroxy-3,3-dimethylbutyl]-

1455031-68-1: The chemical substance known as Urea, N-[2-fluoro-4-methyl-5-[2-methyl-7-(methylamino)-1,6-naphthyridin-3-yl]phenyl]-N′-[(2S)-2-hydroxy-3,3-dimethylbutyl]- (CAS 1455031-68-1) is a complex organic compound characterized by its urea functional group, which is central to its structure. This compound features a fluorinated aromatic ring and a naphthyridine moiety, contributing to its potential biological activity. The presence of a hydroxyl group on a branched alkyl chain suggests possible interactions with biological targets, enhancing its solubility and reactivity. The methylamino group indicates potential for hydrogen bonding, which may influence its pharmacokinetic properties. Overall, this compound's intricate structure may confer specific properties that could be relevant in medicinal chemistry, particularly in the development of pharmaceuticals targeting various biological pathways. Its unique combination of functional groups and structural features may also affect its stability, reactivity, and interaction with other molecules.

<p>LSN3074753, a derivative of LY3009120, acts as a pan-RAF and Raf dimer inhibitor. This compound exhibits inhibitory activity against tumor cells driven by either BRAF monomers or RAF dimers, particularly in the activation of the MAPK pathway, including colorectal cancers with BRAF or KRAS mutations. When combined with Cetuximab, LSN3074753 demonstrates additive and synergistic effects in colorectal cancer PDX models, especially in those harboring KRAS or BRAF mutations.</p>

CAS 1455031-68-1

Urea, N-[2-fluoro-4-methyl-5-[2-methyl-7-(methylamino)-1,6-naphthyridin-3-yl]phenyl]-N′-[(2S)-2-hydroxy-3,3-dimethylbutyl]-

LSN3074753

Ref: TM-T89906