CAS 14556-46-8

(±)-Bupranolol

Description:

(±)-Bupranolol is a non-selective beta-adrenergic antagonist, primarily used in the treatment of hypertension and certain types of cardiac arrhythmias. It is characterized by its ability to block both beta-1 and beta-2 adrenergic receptors, which helps in reducing heart rate and blood pressure. The compound is a racemic mixture, meaning it contains equal parts of two enantiomers, which can exhibit different pharmacological effects. Bupranolol is typically administered orally and is known for its relatively moderate lipophilicity, allowing it to cross biological membranes effectively. Its chemical structure includes a phenolic hydroxyl group and a secondary amine, contributing to its pharmacological activity. The substance is also associated with potential side effects, such as fatigue, dizziness, and gastrointestinal disturbances, which are common among beta-blockers. As with other medications in its class, careful monitoring is essential to manage dosage and mitigate adverse effects. Overall, (±)-Bupranolol plays a significant role in cardiovascular therapy, demonstrating the importance of beta-blockers in clinical practice.

Formula: C₁₄H₂₂ClNO₂

InChI: InChI=1S/C14H22ClNO2/c1-10-5-6-12(15)13(7-10)18-9-11(17)8-16-14(2,3)4/h5-7,11,16-17H,8-9H2,1-4H3

InChI key: InChIKey=HQIRNZOQPUAHHV-UHFFFAOYSA-N

SMILES: O(CC(CNC(C)(C)C)O)C1=C(Cl)C=CC(C)=C1

Synonyms:

• 1-(2-Chloro-5-methylphenoxy)-3-[(1,1-dimethylethyl)amino]-2-propanol
• 1-(Tert-Butylamino)-3-(2-Chloro-5-Methylphenoxy)Propan-2-Ol
• 1-(tert-Butylamino)-3-((6-chloro-m-tolyl)-oxy)-2-propanol
• 1-t-Butylamino-3-(2-chloro-5-methylphenoxy) -2-propanol
• 2-Propanol, 1-(2-chloro-5-methylphenoxy)-3-((1,1-dimethylethyl)amino)-
• 2-Propanol, 1-(tert-butylamino)-3-((6-chloro-m-tolyl)oxy)- (8CI)
• 2-Propanol, 1-(tert-butylamino)-3-(2-chloro-5-methylphenoxy)-
• 2-Propanol, 1-(tert-butylamino)-3-(6-chloro-m-tolyloxy)-
• 2-Propanol, 1-(tert-butylamino)-3-[(6-chloro-m-tolyl)oxy]-
• 3-(tert-Butylamino)-1-(6-chloro-m-tolyloxy)-2-propanol
• Brn 2272923
• Bupranol
• Bupranolol [INN:DCF]
• Bupranololum
• Bupranololum [INN-Latin]
• Kl 255
• Ophtorenin
• Sk&F 16805-A
• Unii-858Ygi5Pit
• Bupranolol

Bupranolol

CAS: 14556-46-8

Formula: C₁₄H₂₂ClNO₂

Purity: 95%

Color and Shape: Solid

Molecular weight: 271.7830

Ref: IN-DA00ADTL

Bupranolol

CAS: 14556-46-8

Bupranolol

Purity: ≥95%

Molecular weight: 271.78g/mol

Ref: 54-BUP09422

Bupranolol

CAS: 14556-46-8

Bupranolol blocks β2-adrenergic receptor; treats angina, hypertension, glaucoma, arrhythmia, and prevents clots.

Formula: C₁₄H₂₂ClNO₂

Purity: 97.63%

Color and Shape: Solid

Molecular weight: 271.78

Ref: TM-T8580

Bupranolol-d9

Controlled Product

CAS: 14556-46-8

Applications Isotope labelled Bupranolol is an antagonist at the cardiostimulatory low-affinity state of b(1)-adrenoceptors and is known to treat hypertension and tachycardia.
References Zelaszczyk, D., et al.: J. Physiol. Pharmacol., 60, 51 (2009); Wachter, W., et al.: Naunyn. Schmiedebergs. Arch. Pharmacol., 313, 1 (1980);

Formula: C₁₄H₁₃D₉ClNO₂

Color and Shape: Neat

Molecular weight: 280.84

Ref: TR-B689652

Bupranolol

Controlled Product

CAS: 14556-46-8

Applications Bupranolol is an antagonist at the cardiostimulatory low-affinity state of b(1)-adrenoceptors and is known to treat hypertension and tachycardia.
References Zelaszczyk, D., et al.: J. Physiol. Pharmacol., 60, 51 (2009); Wachter, W., et al.: Naunyn. Schmiedebergs. Arch. Pharmacol., 313, 1 (1980);

Formula: C₁₄H₂₂ClNO₂

Color and Shape: Neat

Molecular weight: 271.78

Ref: TR-B689650

Bupranolol

CAS: 14556-46-8

Bupranolol is a chiral compound that has been used to study the involvement of fat cells in the development of hypertension. Bupranolol is a beta-adrenergic receptor antagonist that binds to and inhibits the activity of beta-adrenergic receptors on fat cells, which decreases the breakdown of fatty acids and lowers blood pressure. The effects of bupranolol on mice with an experimental model of urinary bladder dysfunction have been studied using monoclonal antibodies. Results show that bupranolol can relax detrusor muscle and increase urethral sphincter pressure, thereby treating urinary incontinence. The pharmacological treatment for cardiac arrhythmias such as supraventricular tachycardia, atrial fibrillation, and ventricular tachycardia includes intravenous administration of bupranolol. This drug can also be given orally or intramuscularly for other cardiovascular conditions such as angina pectoris and cardiogenic

Formula: C₁₄H₂₂ClNO₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 271.78 g/mol

Ref: 3D-FB180511