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CAS 145576-25-6

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ACETYLSIMVASTATIN

Description:
Acetylsimvastatin is a synthetic derivative of simvastatin, which is a member of the statin class of drugs primarily used to lower cholesterol levels in the blood. Its chemical structure features a lactone ring and a hydroxy acid moiety, which are characteristic of statins. Acetylsimvastatin functions by inhibiting HMG-CoA reductase, an enzyme crucial for cholesterol biosynthesis in the liver, thereby reducing the production of cholesterol and promoting the uptake of low-density lipoprotein (LDL) from the bloodstream. This compound is typically administered in oral form and is known for its lipid-lowering effects, which can help reduce the risk of cardiovascular diseases. In terms of solubility, acetylsimvastatin is generally more soluble in organic solvents than in water, which can influence its bioavailability and pharmacokinetics. As with other statins, potential side effects may include muscle pain, liver enzyme abnormalities, and gastrointestinal disturbances. Overall, acetylsimvastatin represents an important therapeutic agent in the management of dyslipidemia and cardiovascular health.
Formula:C27H40O6
InChI:InChI=1/C27H40O6/c1-7-27(5,6)26(30)33-23-13-16(2)12-19-9-8-17(3)22(25(19)23)11-10-20-14-21(31-18(4)28)15-24(29)32-20/h8-9,12,16-17,20-23,25H,7,10-11,13-15H2,1-6H3/t16-,17-,20+,21+,22-,23-,25-/m0/s1
Synonyms:
  • (1S,3R,7S,8S,8aR)-8-{2-[(2R,4R)-4-(acetyloxy)-6-oxotetrahydro-2H-pyran-2-yl]ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2,2-dimethylbutanoate
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