CAS 145599-86-6

Cerivastatin

Description:

Cerivastatin is a synthetic lipid-lowering agent belonging to the statin class, primarily used to manage hyperlipidemia and reduce the risk of cardiovascular disease. It functions by inhibiting the enzyme HMG-CoA reductase, which plays a crucial role in cholesterol biosynthesis in the liver. This inhibition leads to decreased cholesterol levels in the bloodstream and promotes the uptake of low-density lipoprotein (LDL) cholesterol by the liver. Cerivastatin is characterized by its potent efficacy in lowering LDL cholesterol and triglycerides while potentially raising high-density lipoprotein (HDL) cholesterol levels. However, it is important to note that cerivastatin was withdrawn from the market due to safety concerns, particularly the risk of severe muscle-related side effects, including rhabdomyolysis. Its chemical structure includes a specific arrangement of functional groups that contribute to its biological activity. As with other statins, cerivastatin's use requires careful monitoring of liver function and muscle health in patients.

Formula: C₂₆H₃₃FNNaO₅

InChI: InChI=1/C26H32FNO4/c1-15(2)25-21(11-10-20-12-19(29)13-23(30)32-20)24(17-6-8-18(27)9-7-17)22(14-31-5)26(28-25)16(3)4/h6-11,15-16,19-20,29H,12-14H2,1-5H3/b11-10+/t19-,20-/m1/s1

InChI key: InChIKey=SEERZIQQUAZTOL-ANMDKAQQSA-N

SMILES: C(=C/[C@H](C[C@H](CC(O)=O)O)O)\C=1C(=C(COC)C(C(C)C)=NC1C(C)C)C2=CC=C(F)C=C2

Synonyms:

• (3R,5S,6E)-7-[4-(4-Fluorophenyl)-5-(methoxymethyl)-2,6-bis(1-methylethyl)-3-pyridinyl]-3,5-dihydroxy-6-heptenoic acid
• (3R,5S,6E)-7-[4-(4-fluorophenyl)-5-(methoxymethyl)-2,6-di(propan-2-yl)pyridin-3-yl]-3,5-dihydroxyhept-6-enoic acid
• (3R,5S,6E)-7-[4-(p-Fluorophenyl)-2,6-diisopropyl-5-(methoxymethyl)-3-pyridyl]-3,5-dihydroxy-6-heptenoic acid
• (4R,6S)-6-{(E)-2-[4-(4-fluorophenyl)-5-(methoxymethyl)-2,6-di(propan-2-yl)pyridin-3-yl]ethenyl}-4-hydroxytetrahydro-2H-pyran-2-one
• 6-Heptenoic acid, 7-[4-(4-fluorophenyl)-5-(methoxymethyl)-2,6-bis(1-methylethyl)-3-pyridinyl]-3,5-dihydroxy-, (3R,5S,6E)-
• 6-Heptenoic acid, 7-[4-(4-fluorophenyl)-5-(methoxymethyl)-2,6-bis(1-methylethyl)-3-pyridinyl]-3,5-dihydroxy-, [S-[R*,S*-(E)]]-
• 7-[4-(4-Fluorophenyl)-5-(Methoxymethyl)-2,6-Dipropan-2-Yl-Pyrid In-3-Yl]-3,5-Dihydroxy-Hept-6-Enoate
• Baychol
• Cerivastatin
• sodium 7-[4-(4-fluorophenyl)-5-(methoxymethyl)-2,6-dipropan-2-yl-pyrid in-3-yl]-3,5-dihydroxy-hept-6-enoate
• CERIVASTATIN, SODIUM SALT
• BAYCOL
• LIPOBAY
• RIVASTATIN
• CERIVASTATIN SODIUM

6-Heptenoic acid, 7-[4-(4-fluorophenyl)-5-(methoxymethyl)-2,6-bis(1-methylethyl)-3-pyridinyl]-3,5-dihydroxy-, (3R,5S,6E)-

CAS: 145599-86-6

Formula: C₂₆H₃₄FNO₅

Purity: 95%

Molecular weight: 459.5503

Ref: IN-DA001D7D

Cerivastatin

CAS: 145599-86-6

Cerivastatin

Purity: ≥95%

Molecular weight: 459.55g/mol

Ref: 54-BUP04167

Cerivastatin

CAS: 145599-86-6

An inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase that reduces total cholesterol and low-density lipoprotein (LDL). Cerivastatin is cardioprotective and anti-atherosclerotic. Cerivastatin inhibits the expression of the atherosclerotic genes monocyte chemoattractant protein-1 (MCP-1) and C-C chemokine receptor type 2 (CCR2), whilst inducing the expression of Kruppel-like factor 2 (KLF2).

Formula: C₂₆H₃₄FNO₅

Purity: Min. 95%

Molecular weight: 459.55 g/mol

Ref: 3D-FC103389

Cerivastatin

CAS: 145599-86-6

Cerivastatin is an HMG-CoA reductase inhibitor with anticancer and lipid-lowering effects and can be used to study primary hyperlipidemia.

Formula: C₂₆H₃₄FNO₅

Purity: 97.80% - 99.56%

Color and Shape: Solid

Molecular weight: 459.55

Ref: TM-T14931